3114073-95-6
Chemical Structure
EB-TCIP
Synonym(s): BAK-04-212
- CAS No.: 3114073-95-6
- Formula:C68H86ClN9O15
- Molecular Weight:1304.91
InChIKey: FXKSJPXJSRKKRH-ZUILBJGRSA-N
SMILES: COC1=C(OC)C=C([C@@H](C(N2CCCC[C@H]2C(O[C@@H](C3=CC=CC=C3OCC(NCCCCCCNC(C4CCN(C5=NC(NC(C=C6OC)=CC7=C6N(C(C(OCC(NC)=O)=C7)=O)C)=C(Cl)C=N5)CC4)=O)=O)CCC8=CC=C(OC)C(OC)=C8)=O)=O)CC)C=C1OC
Biological Activity:
EB-TCIP (BAK-04-212) is a proof-of-concept tool specifically designed for Ewing sarcoma research, serving as an EWSR1::FLI1 binder tagged with BCL6 and FKBP12F36V. EB-TCIP forms a ternary complex with the tagged fusion protein, specifically recruits EWSR1::FLI1 to BCL6-bound DNA loci, and induces rapid chromatin remodeling and relocalization. By mediating relocalization, EB-TCIP remodels the transcriptional machinery and activates the expression of BCL6 target genes that are originally repressed. EB-TCIP is used in studies related to novel epigenetic therapies for Ewing sarcoma[1].
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EB-TCIP | 99.58% | EB-TCIP (BAK-04-212) is a proof-of-concept tool specifically designed for Ewing sarcoma research, serving as an EWSR1::FLI1 binder tagged with BCL6 and FKBP12F36V. EB-TCIP forms a ternary complex with the tagged fusion protein, specifically recruits EWSR1::FLI1 to BCL6-bound DNA loci, and induces rapid chromatin remodeling and relocalization. By mediating relocalization, EB-TCIP remodels the transcriptional machinery and activates the expression of BCL6 target genes that are originally repressed. EB-TCIP is used in studies related to novel epigenetic therapies for Ewing sarcoma. |
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Keywords
