3 Results for "

Gliotoxin

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Gliotoxin" in MCE Product Catalog:

2
Gliotoxin
Gliotoxin
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2 Cited Publications
Cat. No.: HY-N6727
CAS No.: 67-99-2
Synonyms: Aspergillin
Category:  

Anti-inflammation/Immunoregulatory Disease Research Antibacterial Biological Pesticide Research Other Antibiotics Agricultural Research Infection Microorganisms Antibiotics Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis PKA NF-κB Bacterial Fungal Antibiotic

Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells . Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis . Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells . Gliotoxin is a potent NOTCH2 transactivation inhibitor, can effectively induce apoptosis of chronic lymphocytic leukemia (CLL) cells .
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Bis(methylthio)gliotoxin
Bis(methylthio)gliotoxin
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Cat. No.: HY-N9710
CAS No.: 74149-38-5
Synonyms: Bisdethiobis(methylthio)Gliotoxin; FR 49175; DimethylGliotoxin
Category:  

Infection Alkaloids Microorganisms Other Alkaloids Disease Research Fields

Target:  

Fungal

Bis(methylthio)gliotoxin is a more stable and reliable marker for invasive aspergillosis than gliotoxin and suitable for use in diagnosis .
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Acetylgliotoxin
Acetylgliotoxin
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Cat. No.: HY-183421
CAS No.: 146016-64-0
Synonyms: Gliotoxin monoacetate
Target:  

Farnesyl Transferase Fungal Bacterial Reactive Oxygen Species (ROS)

Research Areas:  

Infection

Acetylgliotoxin (Gliotoxin monoacetate) is a farnesyltransferase (FTase) inhibitor with an IC50 of 4.4 μM against human targets. Acetylgliotoxin inhibits the growth of fungal, bacterial, and viral pathogens; it binds to free protein thiols and induces ROS production. Acetylgliotoxin increases the survival rate of Caenorhabditis elegans infected with Candida albicans, but exhibits toxicity at higher concentrations. Acetylgliotoxin is applicable to research related to Candida albicans infections .
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