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Cat. No.: HY-183421

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Acetylgliotoxin

Name: Acetylgliotoxin
Brand: MedChemExpress
SKU: HY-183421
Availability: PreOrder

(Synonyms: Gliotoxin monoacetate)

Acetylgliotoxin (Gliotoxin monoacetate) is a farnesyltransferase (FTase) inhibitor with an IC₅₀ of 4.4 μM against human targets. Acetylgliotoxin inhibits the growth of fungal, bacterial, and viral pathogens; it binds to free protein thiols and induces ROS production. Acetylgliotoxin increases the survival rate of Caenorhabditis elegans infected with Candida albicans, but exhibits toxicity at higher concentrations. Acetylgliotoxin is applicable to research related to Candida albicans infections.

For research use only. We do not sell to patients.

CAS No.: 146016-64-0
Formula: C₁₅H₁₆N₂O₅S₂
Molecular Weight:368.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Acetylgliotoxin Chemical Structure

CAS No.: 146016-64-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
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References
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.89 μM Compound: 361	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 38181652]
HEK293	IC₅₀	4.49 μM Compound: 361	Cytotoxicity against HEK293 cells assessed as cell growth inhibition Cytotoxicity against HEK293 cells assessed as cell growth inhibition	[PMID: 38181652]
HepG2	IC₅₀	0.49 μM Compound: 361	Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by SRB assay Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by SRB assay	[PMID: 38181652]
HepG2	IC₅₀	0.32 μM Compound: 361	Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay	[PMID: 38181652]
MCF7	IC₅₀	0.22 μM Compound: 361	Cytotoxicity against human MCF7 cells assessed as reduction in cell growth incubated for 48 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as reduction in cell growth incubated for 48 hrs by SRB assay	[PMID: 38181652]
NCI-H460	IC₅₀	0.32 μM Compound: 361	Cytotoxicity against human NCI-H460 cells assessed as reduction in cell growth incubated for 48 hrs by SRB assay Cytotoxicity against human NCI-H460 cells assessed as reduction in cell growth incubated for 48 hrs by SRB assay	[PMID: 38181652]
NCI-H460	IC₅₀	0.49 μM Compound: 361	Cytotoxicity against human NCI-H460 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay Cytotoxicity against human NCI-H460 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay	[PMID: 38181652]
RKO	IC₅₀	1.24 μM Compound: 361	Cytotoxicity against human RKO cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Cytotoxicity against human RKO cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38181652]
SF-268	IC₅₀	0.25 μM Compound: 361	Cytotoxicity against human SF-268 cells assessed as reduction in cell growth incubated for 48 hrs by SRB assay Cytotoxicity against human SF-268 cells assessed as reduction in cell growth incubated for 48 hrs by SRB assay	[PMID: 38181652]

In Vitro

Acetylgliotoxin (AGT) (30 minutes) inhibits farnesyl-protein transferase from human monocyte THP-1 cells in its reduced dithiol form with an IC₅₀ of 4.4 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Acetylgliotoxin (compound A3) (0-2 μM; in assay medium) confers a 73% maximum survival rate to C. albicans-infected Caenorhabditis elegans glp-4;sek-1 mutants, with reduced survival at concentrations > 16 μg/mL due to toxicity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 146016-64-0
Molecular Weight 368.43
Formula C₁₅H₁₆N₂O₅S₂
SMILES

O=C1[C@@]23N(C([C@](N1C)(SS3)CO)=O)[C@@]4([H])C(C2)=CC=C[C@@H]4OC(C)=O
Synonyms

Gliotoxin monoacetate
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. van der Pyl D, et al. Inhibition of farnesyl-protein transferase by gliotoxin and acetylgliotoxin. J Antibiot. 1992;45(11):1802-1805.

[2]. Coleman JJ, et al. Antifungal activity of microbial secondary metabolites. PloS one. 2011;6(9):e25321. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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