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Cat. No.: HY-183421

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Acetylgliotoxin

(Synonyms: Gliotoxin monoacetate)

Acetylgliotoxin (Gliotoxin monoacetate) is a farnesyltransferase (FTase) inhibitor with an IC₅₀ of 4.4 μM against human targets. Acetylgliotoxin inhibits the growth of fungal, bacterial, and viral pathogens; it binds to free protein thiols and induces ROS production. Acetylgliotoxin increases the survival rate of Caenorhabditis elegans infected with Candida albicans, but exhibits toxicity at higher concentrations. Acetylgliotoxin is applicable to research related to Candida albicans infections.

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CAS No.: 146016-64-0
Formule: C₁₅H₁₆N₂O₅S₂
Masse moléculaire:368.43

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Acetylgliotoxin Chemical Structure

CAS No.: 146016-64-0

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

Acetylgliotoxin (AGT) (30 minutes) inhibits farnesyl-protein transferase from human monocyte THP-1 cells in its reduced dithiol form with an IC₅₀ of 4.4 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Acetylgliotoxin (compound A3) (0-2 μM; in assay medium) confers a 73% maximum survival rate to C. albicans-infected Caenorhabditis elegans glp-4;sek-1 mutants, with reduced survival at concentrations > 16 μg/mL due to toxicity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 146016-64-0
Masse moléculaire 368.43
Formule C₁₅H₁₆N₂O₅S₂
SMILES

O=C1[C@@]23N(C([C@](N1C)(SS3)CO)=O)[C@@]4([H])C(C2)=CC=C[C@@H]4OC(C)=O
Synonyms

Gliotoxin monoacetate
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. van der Pyl D, et al. Inhibition of farnesyl-protein transferase by gliotoxin and acetylgliotoxin. J Antibiot. 1992;45(11):1802-1805.

[2]. Coleman JJ, et al. Antifungal activity of microbial secondary metabolites. PloS one. 2011;6(9):e25321. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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