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Results for "

Human TNF mRNA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	mRNA (11) TNF Receptor (5) Adenosine Kinase (1) Bacterial (1) Cholinesterase (ChE) (1) Connexin (1) Fungal (1) IFNAR (1) Interleukin Related (1) p38 MAPK (1) Parasite (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (2) Infection (3) Inflammation/Immunology (11) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	mRNA (11) Antisense Oligonucleotides (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Inhibitory Antibodies

Natural
Products

Oligonucleotides

Targets Recommended: mRNA TNF Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-159069

Zymosan (ZM), 95%	Toll-like Receptor (TLR) TNF Receptor Connexin	Infection Cancer
Zymosan (ZM), 95% is a yeast cell wall-derived carbohydrate-rich preparation and immunomodulator. Zymosan (ZM), 95% binds to and activates TLR-2, TLR-4, and Dectin-1 receptor to trigger downstream signaling pathways. Zymosan (ZM), 95% upregulates TLR-2, TLR-4, and *TNF-α* mRNA expression, increases serum *TNF-α* levels, and stimulates splenocyte number and viability in mice. Zymosan (ZM), 95% attenuates melanoma growth progression, modulates macrophage marker gene expression, and mediates phagocytosis, ROS generation, and cytokine production. Zymosan (ZM), 95% reduces Connexin 43 protein and mRNA levels, inhibits gap junctional intercellular communication, and induces proinflammatory factor production in human corneal cells. Zymosan (ZM), 95% induces peritoneal inflammation in mice, functions as a drug carrier, and supports fibroblast cell attachment in hydrogel formulations. Zymosan (ZM), 95% can be used for the research of melanoma, tumors, fungal keratitis, ocular surface inflammatory disorders, and peritoneal inflammation .

HY-145726

ISIS 104838	TNF Receptor	Cardiovascular Disease Inflammation/Immunology
ISIS 104838 is an antisense oligonucleotide targeting *TNF-α. ISIS 104838 specifically binds to human* TNF-α mRNA via Watson-Crick base pairing to form a DNA:RNA hybrid duplex, thereby recruiting the ubiquitously expressed intracellular enzyme RNase H to degrade the target mRNA and inhibit TNF-α protein synthesis at the transcriptional level. ISIS 104838 induces moderate, self-limiting thrombocytopenia in cynomolgus monkeys. ISIS 104838 can be used for the study of inflammatory diseases .

HY-N10423

Cubebin (-)-Cubebin	Cholinesterase (ChE) Bacterial Fungal Parasite p38 MAPK	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cubebin ((-)-Cubebin), a dibenzyl butyrolactone lignan, is an orally active AChE inhibitor. Cubebin binds to active sites of NF-κB, *TNF-α, and TGF-β1* via hydrogen and hydrophobic interactions, obstructing critical residues to inhibit pro-inflammatory or renal fibrosis-related activity. Cubebin enhances p38 MAPK phosphorylation to increase tyrosinase gene expression, stimulating melanogenesis via elevated tyrosinase activity, expression, and mRNA levels. Cubebin reduces oxidative stress via enhanced endogenous antioxidant enzyme activity and inhibited lipid peroxidation, regulates lipid metabolism, improves glycemic control, and exerts renoprotective effects via reduced renal dysfunction markers and improved renal architecture. Cubebin shows antimicrobial activity. Cubebin exerts larvicidal activity against Angiostrongylus cantonensis larvae, with no cytotoxicity toward monkey or human cell lines or Caenorhabditis elegans. Cubebin can be used for the research of diabetic nephropathy, melanoma, colon adenocarcinoma, neuroangiostrongyliasis, Alzheimer’s disease (AD) and depression .

HY-145726A

ISIS 104838 sodium	TNF Receptor	Cardiovascular Disease Inflammation/Immunology
ISIS 104838 sodium is an antisense oligonucleotide targeting *TNF-α. ISIS 104838 sodium specifically binds to human* TNF-α mRNA via Watson-Crick base pairing to form a DNA:RNA hybrid duplex, thereby recruiting the ubiquitously expressed intracellular enzyme RNase H to degrade the target mRNA and inhibit TNF-α protein synthesis at the transcriptional level. ISIS 104838 sodium induces moderate, self-limiting thrombocytopenia in cynomolgus monkeys. ISIS 104838 sodium can be used for the study of inflammatory diseases .

HY-174736

**Human CD70 mRNA**	mRNA	Inflammation/Immunology
Human CD70 mRNA encodes the human CD70 molecule (CD70) protein, a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. CD70 induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. It is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

HY-174518

**Human TNF mRNA**	mRNA	Cancer
Human TNF mRNA encodes the human tumor necrosis factor (TNF) protein, a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. TNF is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation.

HY-174515

**Human TNFRSF1B mRNA**	mRNA	Cancer
Human TNFRSF1B mRNA encodes the human TNF receptor superfamily member 1B (TNFRSF1B) protein, a member of the TNF receptor superfamily.

HY-174514

**Human TNFRSF4 mRNA**	mRNA	Cancer
Human TNFRSF4 mRNA encodes the human TNF receptor superfamily member 4 (TNFRSF4) protein, a member of the TNF receptor superfamily. TNFRSF4 has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5.

HY-174513

**Human TNFRSF8 mRNA**	mRNA	Inflammation/Immunology
Human TNFRSF8 mRNA encodes the human TNF receptor superfamily member 8 (TNFRSF8) protein, a member of the TNF receptor superfamily. TNFRSF8 is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.

HY-174512

**Human TNFSF8 mRNA**	mRNA	Cancer
Human TNFSF8 mRNA encodes the human TNF superfamily member 8 (TNFSF8) protein, a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TNFSF8 was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines.

HY-174738

**Human CD40 mRNA**	mRNA	Inflammation/Immunology
Human CD40 mRNA encodes the human CD40 molecule (CD40) protein, a member of the TNF-receptor superfamily. CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.

HY-P991408

DLX-105	TNF Receptor Interleukin Related IFNAR	Inflammation/Immunology
DLX-105 is a human monoclonal antibody (mAb) targeting TNFSF2/TNFa. DLX-105 reduces skin epidermal thickness and the expression of K16 and Ki67. DLX-105 down-regulates the mRNA levels of IL-17, TNF-α, IL-23p19, IL-12p40, and IFN-γ. DLX-105 can be used in psoriasis research .

HY-174516

**Human TNFRSF1A mRNA**	mRNA	Cancer
Human TNFRSF1A mRNA encodes the human TNF receptor superfamily member 1A (TNFRSF1A) protein, a member of the TNF receptor superfamily.

HY-N12104

Trichodimerol BMS-182123	TNF Receptor	Infection
Trichodimerol (BMS-182123) is a *TNF-α* promoter inhibitor that inhibits the activity of lipopolysaccharide-induced cytokine secretion. Trichodimerol inhibits lipopolysaccharide-induced *TNF-α* promoter activity, reduces steady-state *TNF-α* mRNA expression, and does not alter the stability of *TNF-α* mRNA. Trichodimerol inhibits lipopolysaccharide-induced *TNF-α* secretion in murine and human immune cells. Trichodimerol reduces lipopolysaccharide-induced IL-1β secretion by 25%-50% in vitro. Trichodimerol does not alter total protein synthesis or constitutive lysozyme secretion at effective concentrations. Trichodimerol can be used for the research of septic shock .

HY-174587

**Human LTB mRNA**	mRNA	Inflammation/Immunology
Human LTB mRNA encodes the human lymphotoxin beta (LTB) protein, a type II membrane protein of the TNF family. LTB is an inducer of the inflammatory response system and also involved in normal development of lymphoid tissue.

HY-174517

**Human TNFRSF14 mRNA**	mRNA	Inflammation/Immunology
Human TNFRSF14 mRNA encodes the human TNF receptor superfamily member 14 (TNFRSF14) protein, a member of the TNF receptor superfamily. TNFRSF14 functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells.

HY-174714

**Human FAS mRNA**	mRNA	Inflammation/Immunology
Human FAS mRNA encodes the human Fas cell surface death receptor (FAS) protein, a member of the TNF-receptor superfamily. FAS has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system.

HY-182503

GP515	Adenosine Kinase	Others Inflammation/Immunology
GP515 is a potent and selective adenosine kinase inhibitor with a human IC₅₀ of 4 nM. GP515 exerts tissue protective effects, produces long-lasting hepatic microcirculation effects after hemorrhagic shock, and induces dose- and time-related VEGF mRNA and protein expression in normoxic rat myocardial myoblasts, with additive VEGF increases during mild hypoxia and no effect during severe hypoxia. GP515 suppresses IFNγ synthesis and CD69 expression in DSS-induced colitis. GP515 also shows a dose-dependent suppression of *TNF-α* production with an IC₅₀ of 80 μM and can be reversed in the presence of the cAMP antagonist (Rp)-cAMPS. Combinations of GP515 with either adenosine or rolipram led to an additive inhibition of TNF-α synthesis. GP515 can be used for the research of hemorrhagic shock .

Cat. No.	Product Name	Type

HY-159069

Zymosan (ZM), 95%	Biochemical Assay Reagents
Zymosan (ZM), 95% is a yeast cell wall-derived carbohydrate-rich preparation and immunomodulator. Zymosan (ZM), 95% binds to and activates TLR-2, TLR-4, and Dectin-1 receptor to trigger downstream signaling pathways. Zymosan (ZM), 95% upregulates TLR-2, TLR-4, and *TNF-α* mRNA expression, increases serum *TNF-α* levels, and stimulates splenocyte number and viability in mice. Zymosan (ZM), 95% attenuates melanoma growth progression, modulates macrophage marker gene expression, and mediates phagocytosis, ROS generation, and cytokine production. Zymosan (ZM), 95% reduces Connexin 43 protein and mRNA levels, inhibits gap junctional intercellular communication, and induces proinflammatory factor production in human corneal cells. Zymosan (ZM), 95% induces peritoneal inflammation in mice, functions as a drug carrier, and supports fibroblast cell attachment in hydrogel formulations. Zymosan (ZM), 95% can be used for the research of melanoma, tumors, fungal keratitis, ocular surface inflammatory disorders, and peritoneal inflammation .

Zymosan (ZM), 95%

Biochemical Assay Reagents

Zymosan (ZM), 95% is a yeast cell wall-derived carbohydrate-rich preparation and immunomodulator. Zymosan (ZM), 95% binds to and activates TLR-2, TLR-4, and Dectin-1 receptor to trigger downstream signaling pathways. Zymosan (ZM), 95% upregulates TLR-2, TLR-4, and TNF-α mRNA expression, increases serum TNF-α levels, and stimulates splenocyte number and viability in mice. Zymosan (ZM), 95% attenuates melanoma growth progression, modulates macrophage marker gene expression, and mediates phagocytosis, ROS generation, and cytokine production. Zymosan (ZM), 95% reduces Connexin 43 protein and mRNA levels, inhibits gap junctional intercellular communication, and induces proinflammatory factor production in human corneal cells. Zymosan (ZM), 95% induces peritoneal inflammation in mice, functions as a drug carrier, and supports fibroblast cell attachment in hydrogel formulations. Zymosan (ZM), 95% can be used for the research of melanoma, tumors, fungal keratitis, ocular surface inflammatory disorders, and peritoneal inflammation .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991408

DLX-105	TNF Receptor Interleukin Related IFNAR	Inflammation/Immunology
DLX-105 is a human monoclonal antibody (mAb) targeting TNFSF2/TNFa. DLX-105 reduces skin epidermal thickness and the expression of K16 and Ki67. DLX-105 down-regulates the mRNA levels of IL-17, TNF-α, IL-23p19, IL-12p40, and IFN-γ. DLX-105 can be used in psoriasis research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10423

Cubebin (-)-Cubebin	Structural Classification Classification of Application Fields Lignans Piperaceae Piper cubeba L.f. Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Cholinesterase (ChE) Bacterial Fungal Parasite p38 MAPK
Cubebin ((-)-Cubebin), a dibenzyl butyrolactone lignan, is an orally active AChE inhibitor. Cubebin binds to active sites of NF-κB, *TNF-α, and TGF-β1* via hydrogen and hydrophobic interactions, obstructing critical residues to inhibit pro-inflammatory or renal fibrosis-related activity. Cubebin enhances p38 MAPK phosphorylation to increase tyrosinase gene expression, stimulating melanogenesis via elevated tyrosinase activity, expression, and mRNA levels. Cubebin reduces oxidative stress via enhanced endogenous antioxidant enzyme activity and inhibited lipid peroxidation, regulates lipid metabolism, improves glycemic control, and exerts renoprotective effects via reduced renal dysfunction markers and improved renal architecture. Cubebin shows antimicrobial activity. Cubebin exerts larvicidal activity against Angiostrongylus cantonensis larvae, with no cytotoxicity toward monkey or human cell lines or Caenorhabditis elegans. Cubebin can be used for the research of diabetic nephropathy, melanoma, colon adenocarcinoma, neuroangiostrongyliasis, Alzheimer’s disease (AD) and depression .

HY-N12104

Trichodimerol BMS-182123	Structural Classification Natural Products Endogenous metabolite Source Classification	TNF Receptor
Trichodimerol (BMS-182123) is a *TNF-α* promoter inhibitor that inhibits the activity of lipopolysaccharide-induced cytokine secretion. Trichodimerol inhibits lipopolysaccharide-induced *TNF-α* promoter activity, reduces steady-state *TNF-α* mRNA expression, and does not alter the stability of *TNF-α* mRNA. Trichodimerol inhibits lipopolysaccharide-induced *TNF-α* secretion in murine and human immune cells. Trichodimerol reduces lipopolysaccharide-induced IL-1β secretion by 25%-50% in vitro. Trichodimerol does not alter total protein synthesis or constitutive lysozyme secretion at effective concentrations. Trichodimerol can be used for the research of septic shock .

Cat. No.	Product Name		Classification

HY-145726

ISIS 104838		Antisense Oligonucleotides
ISIS 104838 is an antisense oligonucleotide targeting *TNF-α. ISIS 104838 specifically binds to human* TNF-α mRNA via Watson-Crick base pairing to form a DNA:RNA hybrid duplex, thereby recruiting the ubiquitously expressed intracellular enzyme RNase H to degrade the target mRNA and inhibit TNF-α protein synthesis at the transcriptional level. ISIS 104838 induces moderate, self-limiting thrombocytopenia in cynomolgus monkeys. ISIS 104838 can be used for the study of inflammatory diseases .

HY-145726A

ISIS 104838 sodium		Antisense Oligonucleotides
ISIS 104838 sodium is an antisense oligonucleotide targeting *TNF-α. ISIS 104838 sodium specifically binds to human* TNF-α mRNA via Watson-Crick base pairing to form a DNA:RNA hybrid duplex, thereby recruiting the ubiquitously expressed intracellular enzyme RNase H to degrade the target mRNA and inhibit TNF-α protein synthesis at the transcriptional level. ISIS 104838 sodium induces moderate, self-limiting thrombocytopenia in cynomolgus monkeys. ISIS 104838 sodium can be used for the study of inflammatory diseases .

HY-174736

**Human CD70 mRNA**		mRNA
Human CD70 mRNA encodes the human CD70 molecule (CD70) protein, a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. CD70 induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. It is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

HY-174518

**Human TNF mRNA**		mRNA
Human TNF mRNA encodes the human tumor necrosis factor (TNF) protein, a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. TNF is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation.

HY-174515

**Human TNFRSF1B mRNA**		mRNA
Human TNFRSF1B mRNA encodes the human TNF receptor superfamily member 1B (TNFRSF1B) protein, a member of the TNF receptor superfamily.

HY-174514

**Human TNFRSF4 mRNA**		mRNA
Human TNFRSF4 mRNA encodes the human TNF receptor superfamily member 4 (TNFRSF4) protein, a member of the TNF receptor superfamily. TNFRSF4 has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5.

HY-174513

**Human TNFRSF8 mRNA**		mRNA
Human TNFRSF8 mRNA encodes the human TNF receptor superfamily member 8 (TNFRSF8) protein, a member of the TNF receptor superfamily. TNFRSF8 is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.

HY-174512

**Human TNFSF8 mRNA**		mRNA
Human TNFSF8 mRNA encodes the human TNF superfamily member 8 (TNFSF8) protein, a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TNFSF8 was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines.

HY-174738

**Human CD40 mRNA**		mRNA
Human CD40 mRNA encodes the human CD40 molecule (CD40) protein, a member of the TNF-receptor superfamily. CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.

HY-174516

**Human TNFRSF1A mRNA**		mRNA
Human TNFRSF1A mRNA encodes the human TNF receptor superfamily member 1A (TNFRSF1A) protein, a member of the TNF receptor superfamily.

HY-174587

**Human LTB mRNA**		mRNA
Human LTB mRNA encodes the human lymphotoxin beta (LTB) protein, a type II membrane protein of the TNF family. LTB is an inducer of the inflammatory response system and also involved in normal development of lymphoid tissue.

HY-174517

**Human TNFRSF14 mRNA**		mRNA
Human TNFRSF14 mRNA encodes the human TNF receptor superfamily member 14 (TNFRSF14) protein, a member of the TNF receptor superfamily. TNFRSF14 functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells.

HY-174714

**Human FAS mRNA**		mRNA
Human FAS mRNA encodes the human Fas cell surface death receptor (FAS) protein, a member of the TNF-receptor superfamily. FAS has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system.

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Human TNF mRNA

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