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Results for "

HyT

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HyT (13) Anaplastic lymphoma kinase (ALK) (4) Androgen Receptor (1) Apoptosis (3) Autophagy (1) Bcr-Abl (1) Drug Derivative (1) Drug Intermediate (3) E3 Ligase Ligand-Linker Conjugates (2) EGFR (2) Ferroptosis (2) Glutathione Peroxidase (2) Histone Methyltransferase (1) HSP (1) JNK (1) Keap1-Nrf2 (1) Ligands for E3 Ligase (2) PARP (2) PROTACs (1) Reactive Oxygen Species (ROS) (1) Small Interfering RNA (siRNA) (1) STAT (1) Target Protein Ligand-Linker Conjugates (1)
By Research Areas:	Cancer (15) Inflammation/Immunology (4)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Oligonucleotides

Targets Recommended: HyT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-133129

MS1943 4 Publications Verification	HyT Histone Methyltransferase Apoptosis	Inflammation/Immunology Cancer
MS1943 is an orally active selective *HyT* degrader of EZH2 that effectively reduces EZH2 levels in cells. MS1943 has anticancer activity and exhibits cytotoxic effects in a variety of TNBC cells while sparing normal cells. In addition, MS1943 maintains high potency (IC₅₀=120 nM) in inhibiting EZH2 methyltransferase activity and is highly selective for EZH2. (Structure Note: RED, EZH2 ligand (HY-148458); Blue, Hyt (HY-W001578)) .

HY-141676

HyT36	EGFR	Others
HyT36 is a low molecular weight hydrophobic tag that promotes the degradation of fusion protein and pseudokinase Her3 .

HY-W037848

Adamantan-1-ylmethanamine 1-Aminomethyladamantane	Drug Intermediate Ligands for E3 Ligase	Cancer
Adamantan-1-ylmethanamine (1-Aminomethyladamantane) is a Hyt hydrophobic group. Adamantan-1-ylmethanamine can be used in the synthesis of ZX782 (HY-161972) .

HY-164807

SARD279	PROTACs Androgen Receptor	Cancer
SARD279 is a potent and selective Androgen Receptor degrader with DC₅₀ value of 1099 nM. SARD279 can be used in prostate cancer research .(Structure Note: Pink: target protein ligand (HY-117486); Blue,: Hyt (HY-W001578); Black: linker (HY-W004896))

HY-153887

HyT36(-Cl)	EGFR	Others
HyT36(-Cl) is the inactive control compound of HyT36, a small molecule hydrophobic tag compound that can be used in protein folding research .

HY-175527

ALK degrader 2	HyT Anaplastic lymphoma kinase (ALK) Apoptosis	Inflammation/Immunology Cancer
ALK degrader 2 is an orally active ALK HyT degrader that degrades EML4-ALK levels (DC₅₀ = 8 nM) and nucleophosmin (NPM)-ALK protein levels (DC₅₀ = 102 nM). ALK degrader 2 mediates ALK degradation via the Hsp70 chaperone system and ubiquitin-proteasome pathway. ALK degrader 2 induces significant S-phase cell cycle arrest and apoptosis in H3122 cells. ALK degrader 2 shows anti-tumor activity in mice bearing H3122 xenografts. ALK degrader 2 can be used for the study of non-small cell lung cancer (NSCLC). (Pink: ALK ligand (HY-W754809), Blue: Hyt (HY-W013021), Black: Linker (HY-Y1760), ALK ligand-linker conjugate (HY-175528)) .

HY-175849

ALK degrader 1	HyT Anaplastic lymphoma kinase (ALK) Apoptosis STAT	Cancer
ALK degrader 1 is a potent, hydrophobic tag (HyT)-based degrader that induces ubiquitin-proteasome system (UPS)-dependent EML4-ALK degradation (DC₅₀ = 0.13 μM). ALK degrader 1 demonstrates potent ALK degradation and antiproliferative effects in ALK-dependent cell lines, while showing minimal cytotoxicity in ALK fusion-negative cells. ALK degrader 1 triggers cell cycle arrest at the G0/G1 phase and stimulates apoptosis. ALK degrader 1 not only facilitates efficient degradation of the ALK protein but also disrupts key downstream effectors, including the STAT3 signaling axis. ALK degrader 1 mediates robust EML4-ALK degradation in vivo. ALK degrader 1 can be used for ALK-related diseases research .

HY-168682

Adamantane-Butyl alcohol	Target Protein Ligand-Linker Conjugates	Cancer
Adamantane-Butyl alcohol is a selective and persistent degrader targeting the CDK8-cyclin C complex. Adamantane-Butyl alcohol is the linker for LL-K8-22 (PROTAC CDK8-cyclin C, HY-149209) and HyT .

HY-RS15146

Tshr Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tshr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tshr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tshr Mouse Pre-designed siRNA Set A Tshr Mouse Pre-designed siRNA Set A

HY-161972

ZX782	HyT Ferroptosis Glutathione Peroxidase	Cancer
ZX782 is a *HyT* GPX4 degrader and a ferroptosis inducer, which induces GPX4 degradation and significantly increases lipid ROS accumulation in HT1080 cells. ZX782 can be used to treat AD by reducing the size and/or number of brain amyloid plaques and by inhibiting the spread of IL-1beta-positive microglial-like cells around amyloid plaques. ZX782 is labeled with hydrophobic benzyl alcohol (HBA) and appears bright blue under acidic conditions, which can be used for quantitative determination . ZX782 is composed of target protein ligand (red part) ML-210 (HY-100003), PROTAC linker (black part) Bromo-PEG2-CH2-Boc (HY-141371) and Hty molecule (blue part) Adamantan-1-ylmethanamine (HY-W037848). The conjugate consisting of Hyt and linker parts is Adamantan-C-amide-PEG2-C-Br (HY-161974), and the activity control of the target protein ligand is Hydroxyl-ML-210 (HY-161973).

HY-181908

5-Norbornene-2-methylamine-C10-NH2	HyT	Inflammation/Immunology
5-Norbornene-2-methylamine-C10-NH2 is a Keap1-targeting hydrophobic tag (HyT)-linker conjugates, containing a HyT (HY-W022007) and a linker (HY-W014831). 5-Norbornene-2-methylamine-C10-NH2 can be used for synthesis of NBE5 (HY-181907) .

HY-170376

2-(2-Aminoethoxy)ethyl 2-(adamantan-1-yl)acetate	E3 Ligase Ligand-Linker Conjugates	Others
2-(2-Aminoethoxy)ethyl 2-(adamantan-1-yl) acetate is a conjugate of an Hyt hydrophobic group and a linker, which can be used in the synthesis of SARD279 (HY-164807) .

HY-182796

JNK1 degrader-1	HyT JNK	Cancer
JNK1 degrader-1 is a JNK1 *HyT* degrader. JNK1 degrader-1 can induce JNK1 degradation through the *HyT*-mediated ubiquitin-proteasome system and autophagy-lysosome pathway. JNK1 degrader-1 inhibits TGF-β1-induced epithelial-mesenchymal transition (EMT). JNK1 degrader-1 can be used for research on fibrotic diseases and cancer metastasis. (Pink: JNK1 ligand (HY-183006); Blue: Hyt hydrophobic group (HY-W037848); Black: Linker (HY-B1008)) .

HY-180276

PARP1 degrader 1	HyT PARP Drug Derivative Autophagy	Cancer
PARP1 degrader 1 (Compound 2c) is a comparatively potent PARP1 HyT degrader (DC₅₀: 618 nM for intracellular PARP-1). PARP1 degrader 1 is also a HyT-Olaparib (HY-10162) conjugate. PARP1 degrader 1 induces UPR/autophagy, thus facilitating the degradation of PARP-1. PARP1 Degrader 1 can be used in the research of cancer .

HY-185595

N,3-BisBoc-L-Histidine	Drug Intermediate	Others
N,3-BisBoc-L-Histidine is a Hyt hydrophobic group. N,3-BisBoc-L-Histidine can be used in the synthesis of BCR-ABL degrader 1 (HY-180798).

HY-180798

BCR-ABL degrader 1	HyT Bcr-Abl	Cancer
BCR-ABL degrader 1 (Compound 23) is a *HyT*-based BCR-ABL degrader with a DC₅₀ of 19.9 μM. BCR-ABL degrader 1 can be used in the research of chronic myeloid leukemia .

HY-W022007

5-Norbornene-2-methylamine JBP	Ligands for E3 Ligase	Others
5-Norbornene-2-methylamine (JBP) is a hydrophobic tag. 5-Norbornene-2-methylamine can be used for the synthesis of HyT degraders, such as PARP1 degrader-2 (HY-181460) .

HY-161974

Adamantan-C-amide-PEG2-C-Br	E3 Ligase Ligand-Linker Conjugates	Cancer
Adamantan-C-amide-PEG2-C-Br is a conjugate of a Hyt hydrophobic group and a linker. Adamantan-C-amide-PEG2-C-Br can be used to synthesize ZX782 (HY-161972) .

HY-185594

4-(Cyclohexylbuta-1,3-diyn-1-yl)benzoic acid	Drug Intermediate	Others
4-(Cyclohexylbuta-1,3-diyn-1-yl)benzoic acid is a Hyt hydrophobic group. 4-(Cyclohexylbuta-1,3-diyn-1-yl)benzoic acid can be used in the synthesis of PARP1 degrader 1 (HY-180276).

HY-181598

GPX4 degrader-1	HyT Glutathione Peroxidase Ferroptosis Reactive Oxygen Species (ROS)	Cancer
GPX4 degrader-1 (Compound RS-1) is a hydrophobic tagging (HyT)-mediated GPX4 degrader (DC₅₀: 8.9 nM in HT1080 cells) GPX4 degrader-1 induces GPX4 degradation. GPX4 degrader-1 induces Ferroptosis. GPX4 degrader-1 increases lipid ROS. GPX4 degrader-1 demonstrates potent antitumor efficacy in a murine mammary carcinoma model .

HY-182057

ALK degrader 4	HyT Anaplastic lymphoma kinase (ALK)	Cancer
ALK degrader 4 is a ALK HyT degrader with an IC₅₀ of 0.74 nM. ALK degrader 4 inhibits ALK kinase activity, increases the solvent-accessible surface area of hydrophobic residues near the ALK binding pocket, promotes ALK to form a partially unfolded conformation, and induces proteasomal degradation of ALK. ALK degrader 4 inhibits cancer cell proliferation. ALK degrader 4 can be used in research related to non-small cell lung cancer (ALK ligand: Brigatinib (HY-12857); hydrophobic tag: Norbornene (HY-W013021)) .

HY-182087

ALK degrader 3	HyT Anaplastic lymphoma kinase (ALK)	Cancer
ALK degrader 3 is a ALK HyT degrader with an IC₅₀ of 1.2 nM. ALK degrader 3 inhibits ALK kinase activity, increases the solvent-accessible surface area of hydrophobic residues near the ALK binding pocket, promotes ALK to form a partially unfolded conformation, and drives ALK degradation via the proteasomal pathway. ALK degrader 3 inhibits the proliferation of tumor cells. ALK degrader 3 can be used for the research of non-small cell lung cancer. (ALK ligand: Brigatinib (HY-12857); hydrophobic tag: Tetraasterane (HY-W1139353)) .

HY-181460

PARP1 degrader-2	HyT PARP	Cancer
PARP1 degrader-2 (Compound 11e) is a potent, selective PARP1 *HYT* degrader (DC₅₀: 2.16 μM). PARP1 degrader-2 selectively binds to and degrades PARP1 but not PARP2. PARP1 degrader-2 mediates the degradation of PARP1 via the ubiquitin-proteasome system (UPS). PARP1 degrader-2 exhibits anticancer activity against triple-negative breast cancer and colon cancer (hydrophobic tag: (HY-W022007); PARP1 ligand: (HY-75706); Linker: (HY-W015300)) .

HY-181907

NBE5	HyT Keap1-Nrf2 HSP	Inflammation/Immunology
NBE5 is an orally active hydrophobic tag-targeting (Hyt) degrader (HyTTD) that targets Keap1. NBE5 mimics protein misfolding and recruits the molecular chaperone Hsp90, while achieving targeted degradation of Keap1 through both the ubiquitin-proteasome system and the autophagy-lysosome system. Consequently, NBE5 relieves the inhibition of the transcription factor Nrf2 by Keap1, potently activates the Nrf2-mediated endogenous antioxidant pathway, and upregulates the expression of downstream antioxidant proteins such as HO-1 and GCLM. NBE5 effectively alleviates oxidative stress and inflammatory damage, and exhibits excellent in vivo activity in a mouse model of acute colitis induced by DSS (HY-116282C) . NBE5 consists of a hydrophobic tag (HY-W022007), a Keap1-Nrf2 ligand (HY-14909), and a linker (HY-W014831).

Tshr Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Tshr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tshr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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