5-Norbornene-2-methylamine (Synonyms: JBP)

Cat. No.: HY-W022007 Purity: 99.91%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

5-Norbornene-2-methylamine (JBP) is a hydrophobic tag. 5-Norbornene-2-methylamine can be used for the synthesis of HyT degraders, such as PARP1 degrader-2 (HY-181460).

For research use only. We do not sell to patients.

5-Norbornene-2-methylamine Chemical Structure

CAS No. : 95-10-3

Size	Stock	Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Liquid
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	Get quote	Estimated Time of Arrival: December 31
50 g	Get quote	Estimated Time of Arrival: December 31
100 g	Get quote	Estimated Time of Arrival: December 31
> 100 g	Get quote

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•Related Screening Libraries:

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

Biological Activity
Purity & Documentation
References
Customer Review

Description

5-Norbornene-2-methylamine (JBP) is a hydrophobic tag. 5-Norbornene-2-methylamine can be used for the synthesis of HyT degraders, such as PARP1 degrader-2 (HY-181460)^[1].

IC₅₀ & Target^[1]

VHL

In Vitro

5-Norbornene-2-methylamine (4 μM; 24 h) does not induce significant PARP1 degradation in MDA-MB-231 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	MDA-MB-231 triple-negative breast cancer cells
Concentration:	4 μM
Incubation Time:	24 h
Result:	Did not induce significant degradation of PARP1 protein.

Molecular Weight

123.20

Formula

C₈H₁₃N

CAS No.

95-10-3

Appearance

Liquid (Density: 1.000±0.06 g/cm³)

Color

Colorless to light yellow

SMILES

NCC1C(C2)C=CC2C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (1623.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	8.1169 mL	40.5844 mL	81.1688 mL
5 mM	1.6234 mL	8.1169 mL	16.2338 mL
10 mM	0.8117 mL	4.0584 mL	8.1169 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.91%

Select Batch:

Data Sheet (271 KB) SDS (477 KB)

COA (246 KB) HNMR (253 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Li J, et al. Design, synthesis, and biological evaluation of hydrophobic-tagged poly (ADP-ribose) polymerase 1 (PARP1) degraders. Bioorg Chem. 2026;170:109507. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	8.1169 mL	40.5844 mL	81.1688 mL	202.9221 mL
	5 mM	1.6234 mL	8.1169 mL	16.2338 mL	40.5844 mL
	10 mM	0.8117 mL	4.0584 mL	8.1169 mL	20.2922 mL
	15 mM	0.5411 mL	2.7056 mL	5.4113 mL	13.5281 mL
	20 mM	0.4058 mL	2.0292 mL	4.0584 mL	10.1461 mL
	25 mM	0.3247 mL	1.6234 mL	3.2468 mL	8.1169 mL
	30 mM	0.2706 mL	1.3528 mL	2.7056 mL	6.7641 mL
	40 mM	0.2029 mL	1.0146 mL	2.0292 mL	5.0731 mL
	50 mM	0.1623 mL	0.8117 mL	1.6234 mL	4.0584 mL
	60 mM	0.1353 mL	0.6764 mL	1.3528 mL	3.3820 mL
	80 mM	0.1015 mL	0.5073 mL	1.0146 mL	2.5365 mL
	100 mM	0.0812 mL	0.4058 mL	0.8117 mL	2.0292 mL

5-Norbornene-2-methylamine Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Norbornene-2-methylamine95-10-3JBPLigands for E3 LigaseE3 ligase-recruiting MoietyPARP1MDA-MB-231 cellsInhibitorinhibitorinhibit

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