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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
Hyp-dBET1
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "Hyp-dBET1" in MCE Product Catalog:
Cat. No.: HY-173256
Research Areas:
Hyp-dBET1 is a hypoxia-activated BRD4 PROTAC degrader. The IC50 of Hyp-dBET1 for reducing cell viability under hypoxic conditions is approximately 153 nM to 192 nM, while it shows low activity under normoxic conditions (IC50 of approximately 2.8 μM to 3.8 μM). Hyp-dBET1 induces BRD4 degradation under hypoxic conditions, converts to dBET1 in hypoxic environments, and downregulates the expression level of ZFP-91. Hyp-dBET1 can be used in studies related to breast cancer, cervical cancer and solid tumors [1].
Cat. No.: HY-173257
Target:
Research Areas:
Cath-L-dBET1 is a PROTAC degrader targeting BRD4. Cath-L-dBET1 has an IC50 value of 2.8 μM in MDA-MB-231 cells. Cath-L-dBET1 can be activated by cathepsin L (Cath-L) and recruit the E3 ubiquitin ligase and degrade BRD4 through ubiquitin-proteasome system. Hyp-dBET1 can be used for anti-tumor study [1].
Cat. No.: HY-178091
CAS No.: 1995701-00-2
Synonyms: NO2-Ph-C-NH-C4-NHBoc
Target:
Research Areas:
Boc-4-NBA-butyl (NO2-Ph-C-NH-C4-NHBoc) is a PROTAC linker. NO2-Ph-C-NH-C4-NHBoc can be used to synthesize the PROTAC Hyp-dBET1 (HY-173256).
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
