1 Result for "

JH-II-127

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "JH-II-127" in MCE Product Catalog:

Cat. No.: HY-16936
CAS No.: 1700693-08-8
Target:  

LRRK2

Research Areas:  

Neurological Disease

JH-II-127 is an orally active, highly potent, selective and brain-permeable LRRK2 inhibitor, with IC50s of 6, 2 and 48 nM for wild-type LRRK2 and LRRK2-G2019S and mutant LRRK2-A2016T. JH-II-127 inhibits Ser935 phosphorylation in all tissues of mice, including the brain. JH-II-127 can be used in the study of parkinson's syndrome .
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