1700693-08-8
Chemical Structure
JH-II-127
- CAS No.: 1700693-08-8
- Formula:C19H21ClN6O3
- Molecular Weight:416.86
IUPAC Name: (4-((5-chloro-4-(methylamino)-3H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone
InChIKey: HUEKBQXFNHWTQQ-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(NC2=NC3=NC=C(Cl)C3=C(NC)N2)C(OC)=C1)N4CCOCC4
Biological Activity: JH-II-127 is an orally active, highly potent, selective and brain-permeable LRRK2 inhibitor, with IC50s of 6, 2 and 48 nM for wild-type LRRK2 and LRRK2-G2019S and mutant LRRK2-A2016T. JH-II-127 inhibits Ser935 phosphorylation in all tissues of mice, including the brain. JH-II-127 can be used in the study of parkinson's syndrome[1].
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JH-II-127 | 98.0% | JH-II-127 is an orally active, highly potent, selective and brain-permeable LRRK2 inhibitor, with IC50s of 6, 2 and 48 nM for wild-type LRRK2 and LRRK2-G2019S and mutant LRRK2-A2016T. JH-II-127 inhibits Ser935 phosphorylation in all tissues of mice, including the brain. JH-II-127 can be used in the study of parkinson's syndrome. | ||||||||||||||||||||
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Keywords
