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Results for "

KPNB1

" in MedChemExpress (MCE) Product Catalog:

4

Inhibitors & Agonists

1

Recombinant Proteins

1

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-170316
    Ibetazol

    		Ras Cancer
    Ibetazol is a Importin β1 (KPNB1) inhibitor and nucleocytoplasmic transport disruptor. Ibetazol binds covalently to Cys585 of Importin β1, blocks both Importin β1-mediated direct transport and Importin α-dependent nuclear import processes, without affecting transport mediated by other nucleocytoplasmic transport proteins. Ibetazol induces cytoplasmic accumulation of Importin α1, and inhibits nuclear import of substrates carrying nuclear localization signals (NLS), including the NLS-cMyc reporter gene, RelA/p65 and SREBP1. Ibetazol triggers spindle malformation and chromosome misalignment by disrupting the mitotic function of Importin β1. Ibetazol inhibits the proliferation of cells expressing wild-type Importin β1. Ibetazol has a high activity-cytotoxicity window, lacks intrinsic fluorescence, and acts rapidly on nucleocytoplasmic transport processes. Ibetazol serves as a tool compound for investigating nuclear import processes specifically mediated by Importin β1 [1].
    Ibetazol
  • HY-RS25011
    Kpnb1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Kpnb1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Kpnb1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Kpnb1 Rat Pre-designed siRNA Set A
    Kpnb1 Rat Pre-designed siRNA Set A
  • HY-RS07422
    KPNB1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    KPNB1 Human Pre-designed siRNA Set A contains three designed siRNAs for KPNB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    KPNB1 Human Pre-designed siRNA Set A
    KPNB1 Human Pre-designed siRNA Set A
  • HY-RS18529
    Kpnb1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Kpnb1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kpnb1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Kpnb1 Mouse Pre-designed siRNA Set A
    Kpnb1 Mouse Pre-designed siRNA Set A

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