3 Results for "

Kansuinine A

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Kansuinine A" in MCE Product Catalog:

Kansuinine A
Kansuinine A
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Cat. No.: HY-126421
CAS No.: 57701-86-7
Purity:  99.81%
Category:  

Infection Terpenoids Euphorbia kansui T. N. Liou ex S. B. Ho Euphorbiaceae Diterpenoids Plants Disease Research Fields

Target:  

Interleukin Related IKK NF-κB Reactive Oxygen Species (ROS) Bcl-2 Family Caspase LOX-1 Apoptosis

Kansuinine A is a diterpenoid compound. Kansuinine A is isolated from the roots of Euphorbia kansui. Kansuinine A inhibits H2O2-mediated upregulation of phosphorylated IKKβ, NF-κB and IκBα. Kansuinine A inhibits ROS production, reduces the Bax/Bcl-2 ratio and the expression of cleaved Caspase-3. Kansuinine A upregulates the expression of SOCS-3 and blocks IL-6-induced signal transduction. Kansuinine A decreases the expression of LOX-1 and inhibits Apoptosis. Kansuinine A reduces the atherosclerotic lesion area of the aortic arch, improves glucose/insulin tolerance, and enhances antioxidant capacity. Kansuinine A exhibits antiviral and antitumor activities. Kansuinine A can be used in research related to atherosclerosis, liver cancer and type 2 diabetes .
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Kansuinine B
Kansuinine B
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Cat. No.: HY-126420
CAS No.: 57685-46-8
Purity:  ≥99.0%
Category:  

Terpenoids Euphorbia kansui T. N. Liou ex S. B. Ho Euphorbiaceae Diterpenoids Plants Disease Research Fields Inflammation/Immunology

Target:  

SARS-CoV Interleukin Related ERK STAT

Kansuinine B is a natural diterpenoid compound with anti-inflammatory, anti-cancer and anti-viral activities, which can be isolated from the roots of Euphorbia kansui. Kansuinine B induces sustained ERK1/2 activation, inhibits IL-6-induced Stat3 activation and tyrosine phosphorylation, and enhances serine phosphorylation of Stat3. Kansuinine B negatively regulates the IL-6 signaling pathway by upregulating the expression of SOCS-3. Kansuinine B promotes the proliferation of mouse splenic lymphocytes in vitro and stimulates rat peritoneal macrophages to produce NO. Kansuinine B can be used in studies related to liver cancer and COVID-19 .
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Kansuinine E
Kansuinine E
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Cat. No.: HY-N9376
CAS No.: 672945-84-5
Category:  

Terpenoids Euphorbia kansui T. N. Liou ex S. B. Ho Euphorbiaceae Diterpenoids Plants Disease Research Fields Inflammation/Immunology

Target:  

NO Synthase

Kansuinine E is a plant-derived nitric oxide inhibitor (IC50=6.3 μM). Kansuinine E belongs to jatrophane-type diterpenoids and is isolated from the roots of E. kansui .
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