57701-86-7
Chemical Structure
Kansuinine A
- CAS No.: 57701-86-7
- Formula:C37H46O15
- Molecular Weight:730.75
IUPAC Name: (1S,2S,3aR,4R,5R,7R,9S,10S,11S,13R,13aR)-10-(benzoyloxy)-4-hydroxy-2,5,8,8-tetramethyl-12-methylene-6-oxotetradecahydro-3aH-4,7-epoxycyclopenta[12]annulene-1,3a,9,11,13-pentayl pentaacetate
InChIKey: VKHCUWUNVKZFBM-PNKWBUBPSA-N
SMILES: O=C1[C@@]2([H])C(C)(C)[C@H](OC(C)=O)[C@H](OC(C3=CC=CC=C3)=O)[C@@H](OC(C)=O)C([C@H](OC(C)=O)[C@]([C@@H](OC(C)=O)[C@@H](C)C4)([H])[C@@]4(OC(C)=O)[C@@](O2)(O)[C@@H]1C)=C
Biological Activity: Kansuinine A is a diterpenoid compound. Kansuinine A is isolated from the roots of Euphorbia kansui. Kansuinine A inhibits H2O2-mediated upregulation of phosphorylated IKKβ, NF-κB and IκBα. Kansuinine A inhibits ROS production, reduces the Bax/Bcl-2 ratio and the expression of cleaved Caspase-3. Kansuinine A upregulates the expression of SOCS-3 and blocks IL-6-induced signal transduction. Kansuinine A decreases the expression of LOX-1 and inhibits Apoptosis. Kansuinine A reduces the atherosclerotic lesion area of the aortic arch, improves glucose/insulin tolerance, and enhances antioxidant capacity. Kansuinine A exhibits antiviral and antitumor activities. Kansuinine A can be used in research related to atherosclerosis, liver cancer and type 2 diabetes[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Kansuinine A | 99.81% | Kansuinine A is a diterpenoid compound. Kansuinine A is isolated from the roots of Euphorbia kansui. Kansuinine A inhibits H2O2-mediated upregulation of phosphorylated IKKβ, NF-κB and IκBα. Kansuinine A inhibits ROS production, reduces the Bax/Bcl-2 ratio and the expression of cleaved Caspase-3. Kansuinine A upregulates the expression of SOCS-3 and blocks IL-6-induced signal transduction. Kansuinine A decreases the expression of LOX-1 and inhibits Apoptosis. Kansuinine A reduces the atherosclerotic lesion area of the aortic arch, improves glucose/insulin tolerance, and enhances antioxidant capacity. Kansuinine A exhibits antiviral and antitumor activities. Kansuinine A can be used in research related to atherosclerosis, liver cancer and type 2 diabetes. | ||||||||||||||||||||
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References
- [1]. Chen CS, et al. Kansuinine A Ameliorates Atherosclerosis and Human Aortic Endothelial Cell Apoptosis by Inhibiting Reactive Oxygen Species Production and Suppressing IKKβ/IκBα/NF-κB Signaling. International journal of molecular sciences. 2021 Sep 24;22(19):10309. [Content Brief]
- [2]. Chang JS, et al. Kansuinine A and Kansuinine B from Euphorbia kansui L. inhibit IL-6-induced Stat3 activation. Planta medica. 2010 Oct;76(14):1544-9. [Content Brief]
- [3]. Lulji Taraqaz BP, et al. Pancreatic β-cell apoptosis caused by apolipoprotein C3-rich low-density lipoprotein is attenuated by kansuinine A through oxidative stress inhibition. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2025 Jun;187:118066. [Content Brief]
- [4]. Shu X, et al. Bioassay-guided separation of the proinflammatory constituents from the roots of Euphorbia kansui. Journal of natural medicines. 2010 Jan;64(1):98-103. [Content Brief]
