Kansuinine A and Kansuinine B from Euphorbia kansui L. inhibit IL-6-induced Stat3 activation

  • Planta Med. 2010 Oct;76(14):1544-9. doi: 10.1055/s-0030-1249805.
Jong Sun Chang  1 ,  Seung Woong Lee ,  Mi Hye Park ,  Myo Sun Kim ,  Barry I Hudson ,  Su-Jin Park ,  Woo Song Lee ,  Mun-Chual Rho
Affiliations
  • 1. Korea Research Institute of Bioscience and Biotechnology, Jeongeup-si, Korea.
PMID: 20379953 DOI: 10.1055/s-0030-1249805
Abstract

The current study was performed to examine the mechanisms underlying the potential effects of E. KANSUI on IL-6-induced cellular signaling in human hepatoma cells. We found that two Diterpenoids, kansuinine A and B, from E. KANSUI have an inhibitory effect on IL-6-induced STAT3 activation by activating ERK1/2. Inhibition of MEK significantly blocked the effects of kansuinine A and B on IL-6-induced STAT3 activation and tyrosine phosphorylation. These results suggest that blocking of IL-6-induced signal transduction is partially due to the sustained activation of ERK1/2 by kansuinine A and B, which in turn results in an increase of STAT3 serine phosphorylation and SOCS-3 expression. Treatment with kansuinine A and B represents a novel method to block these IL-6-induced effects.

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