57685-46-8
Chemical Structure
Kansuinine B
- CAS No.: 57685-46-8
- Formula:C38H42O14
- Molecular Weight:722.73
IUPAC Name: (1aS,4R,5S,7R,7aS,8R,9R,10S,10aS,12S,12aS)-8,10a-diacetoxy-4,9,10-trihydroxy-2,2,9,12-tetramethyl-6-methylene-3,11-dioxotetradecahydro-2H-cyclopenta[5,6]cyclododeca[1,2-b]oxirene-5,7-diyl dibenzoate
InChIKey: JFOILMZFESGPDU-GXRLDEOZSA-N
SMILES: O=C(C1(C)C)[C@H](O)[C@@H](OC(C2=CC=CC=C2)=O)C([C@H](OC(C3=CC=CC=C3)=O)[C@]([C@@H](OC(C)=O)[C@](C)(O)[C@@H]4O)([H])[C@@]4(OC(C)=O)C([C@@H](C)[C@@]5([H])[C@@]1([H])O5)=O)=C
Biological Activity: Kansuinine B is a natural diterpenoid compound with anti-inflammatory, anti-cancer and anti-viral activities, which can be isolated from the roots of Euphorbia kansui. Kansuinine B induces sustained ERK1/2 activation, inhibits IL-6-induced Stat3 activation and tyrosine phosphorylation, and enhances serine phosphorylation of Stat3. Kansuinine B negatively regulates the IL-6 signaling pathway by upregulating the expression of SOCS-3. Kansuinine B promotes the proliferation of mouse splenic lymphocytes in vitro and stimulates rat peritoneal macrophages to produce NO. Kansuinine B can be used in studies related to liver cancer and COVID-19[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Kansuinine B | 99.0% | Kansuinine B is a natural diterpenoid compound with anti-inflammatory, anti-cancer and anti-viral activities, which can be isolated from the roots of Euphorbia kansui. Kansuinine B induces sustained ERK1/2 activation, inhibits IL-6-induced Stat3 activation and tyrosine phosphorylation, and enhances serine phosphorylation of Stat3. Kansuinine B negatively regulates the IL-6 signaling pathway by upregulating the expression of SOCS-3. Kansuinine B promotes the proliferation of mouse splenic lymphocytes in vitro and stimulates rat peritoneal macrophages to produce NO. Kansuinine B can be used in studies related to liver cancer and COVID-19. | ||||||||||||||||||||
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References
- [1]. Chang JS, et al. Kansuinine A and Kansuinine B from Euphorbia kansui L. inhibit IL-6-induced Stat3 activation. Planta medica. 2010 Oct;76(14):1544-9. [Content Brief]
- [2]. Zhang L, et al. Bio-guided isolation of the cytotoxic terpenoids from the roots of Euphorbia kansui against human normal cell lines L-O2 and GES-1. Int J Mol Sci. 2012;13(9):11247-11259. [Content Brief]
- [3]. Shu X, et al. Bioassay-guided separation of the proinflammatory constituents from the roots of Euphorbia kansui. Journal of natural medicines. 2010 Jan;64(1):98-103. [Content Brief]
- [4]. Uemura, D., et al. (1975). Kansuinine B, a novel multi-oxygenated diterpene from euphorbia kansui liou. Tetrahedron Letters, 16(21), 1703-1706.
- [5]. Yasir Daanial Khan, et al. Promising Compounds for Treatment of Covid-19. VAWKUM Transactions on Computer Sciences, 8(1), 1-8.
