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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
Kit-IN-1
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "Kit-IN-1" in MCE Product Catalog:
Cat. No.: HY-187462
CAS No.: 3080682-21-6
Target:
Research Areas:
Kit-IN-1 is a kinome-selective and orally active KIT inhibitor with a human IC50 value of 2.8 nM. Kit-IN-1 binds to KIT in an allosteric mode, stabilizes the inactive DFG-out conformation of KIT, and blocks the stem cell factor (SCF)-mediated KIT phosphorylation signaling pathway. Kit-IN-1 inhibits SCF-induced ear swelling in rats and prevents increased vascular permeability. Kit-IN-1 can be used in studies related to mast cell-driven chronic inflammation [1].
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25 Publications Verification
Synonyms: GW786034
Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.
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25 Publications Verification
Synonyms: GW786034 Hydrochloride
Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.
11
Dovitinib (CHIR-258) is an orally active, potent multi-targeted tyrosine kinase (RTK) inhibitor with IC50s of 1, 2, 36, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, CSF-1R, FGFR1/FGFR3, VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ, respectively. Dovitinib has potent antitumor activity [1] .
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N-Desethyl Sunitinib (SU-12662) (hydrochloride) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively .
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2 Cited Publications
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c-Kit-IN-1 is a potent inhibitor of c-Kit and c-Met with IC50s of <200 nM.
Cat. No.: HY-P99462
CAS No.: 2438203-51-9
Synonyms: CDX-0159
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Research Areas:
Cat. No.: HY-170517
CAS No.: 3065631-84-4
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Research Areas:
PKMYT1-IN-8 (Compound 137) is the inhibitor for PKMYT1 with an IC50 of 9 nM. PKMYT1-IN-8 inhibits EPHB3, EPHA1, KIT, EPHB1, EPHA2, EPHA3, and EPHB2with IC50s of 1.79, 3.17, 4.29, 6.32, 6.83, 8.10, and 10.9 μM, respectively. PKMYT1-IN-8 inhibits the proliferation of cancer cell OVCAR3 with GI50 of 2.02 μM [1].
Synonyms: GW786034-d6
Cat. No.: HY-10873S
CAS No.: 1217247-62-5
Cat. No.: HY-50905R
CAS No.: 405169-16-6
Synonyms: CHIR-258 (Standard); TKI258 (Standard)
Dovitinib (Standard) is the analytical standard of Dovitinib. This product is intended for research and analytical applications. Dovitinib (CHIR-258) is an orally active, potent multi-targeted tyrosine kinase (RTK) inhibitor with IC50s of 1, 2, 36, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, CSF-1R, FGFR1/FGFR3, VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ, respectively. Dovitinib has potent antitumor activity [1] .
Cat. No.: HY-12009R
CAS No.: 635702-64-6
Synonyms: GW786034 Hydrochloride (Standard)
Pazopanib (Hydrochloride) (Standard) is the analytical standard of Pazopanib (Hydrochloride). This product is intended for research and analytical applications. Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.
Cat. No.: HY-10208R
CAS No.: 444731-52-6
Synonyms: GW786034 (Standard)
Pazopanib (Standard) is the analytical standard of Pazopanib. This product is intended for research and analytical applications. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.
Cat. No.: HY-W705479
CAS No.: 2469755-67-5
Synonyms: GW786034-d3 hydrochloride
Cat. No.: HY-10208S2
CAS No.: 1219591-97-5
Synonyms: GW786034-d3
Cat. No.: HY-50905S
CAS No.: 1246819-84-0
Cat. No.: HY-W011873R
CAS No.: 373-49-9
Synonyms: GW786034-13C,d3 hydrochloride
Cat. No.: HY-10208S1
CAS No.: 1261734-88-6
Synonyms: GW786034-13C,d3
Cat. No.: HY-10873R
CAS No.: 356068-97-8
Synonyms: SU-12662 (Standard)
Target:
Research Areas:
N-Desethyl Sunitinib (Standard) is the analytical standard of N-Desethyl Sunitinib. This product is intended for research and analytical applications. N-Desethyl Sunitinib (SU-12662) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively[1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
