1219591-97-5
1219591-97-5
Chemical Structure
Pazopanib-d3
Synonym(s): GW786034-d3
- CAS No.: 1219591-97-5
- Formula:C21H20D3N7O2S
- Molecular Weight:440.54
IUPAC Name: 5-((4-((2,3-dimethyl-2H-indazol-6-yl)(methyl-d3)amino)pyrimidin-2-yl)amino)-2-methylbenzenesulfonamide
InChIKey: CUIHSIWYWATEQL-HPRDVNIFSA-N
SMILES: O=S(C1=CC(NC2=NC=CC(N(C3=CC4=NN(C(C)=C4C=C3)C)C([2H])([2H])[2H])=N2)=CC=C1C)(N)=O
Biological Activity: Pazopanib-d3 (GW786034-d3) is deuterium labeled Pazopanib. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively[1].
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Pazopanib-d3 | Pazopanib-d3 (GW786034-d3) is deuterium labeled Pazopanib. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively. | |||||||||||||||||||||
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Pazopanib (Standard) | ≥98% | Pazopanib (Standard) is the analytical standard of Pazopanib. This product is intended for research and analytical applications. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively. | ||||||||||||||||||||
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Pazopanib-13C,d3 | Pazopanib-13C,d3 is the deuterium and 13C labeled Pazopanib. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively. | |||||||||||||||||||||
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Pazopanib-d6 | 98.0% | Pazopanib-d6 is the deuterium labeled Pazopanib. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively. | ||||||||||||||||||||
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Pazopanib | 99.91% | Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively. | ||||||||||||||||||||
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References
