2. Protein Tyrosine Kinase/RTK
  3. c-Kit
  4. Barzolvolimab

Barzolvolimab  (Synonyms: CDX 0159)

Cat. No.: HY-P99462 Purity: 99.78%
COA

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Barzolvolimab (CDX 0159) is a humanized anti-KIT IgG1 monoclonal antibody. Barzolvolimab specificity and potently inhibits KIT activation by SCF. Barzolvolimab can reduce skin mast cells and disease activity in chronic inducible urticaria.

For research use only. We do not sell to patients.

Barzolvolimab Chemical Structure

Barzolvolimab Chemical Structure

CAS No. : 2438203-51-9

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Description

Barzolvolimab (CDX 0159) is a humanized anti-KIT IgG1 monoclonal antibody. Barzolvolimab specificity and potently inhibits KIT activation by SCF. Barzolvolimab can reduce skin mast cells and disease activity in chronic inducible urticaria[1].

In Vitro

Barzolvolimab binds the extracellular domain of KIT with high specificity and sub-nanomolar affinity, and allosterically inhibits activation by stem cell factor (SCF)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Barzolvolimab Related Antibodies
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CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Barzolvolimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.78%

COA (231 KB)

Handling Instructions (2659 KB)
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Barzolvolimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Barzolvolimab2438203-51-9CDX 0159CDX0159CDX-0159c-KitSCFRCD117KITIgG1monoclonal antibodySCFchronic inducible urticariaInhibitorinhibitorinhibit

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