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Results for "

LRP5

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) c-Myc (1) Casein Kinase (1) Small Interfering RNA (siRNA) (3) Wnt (7)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Endocrinology (1) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS07800

LRP5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LRP5 Human Pre-designed siRNA Set A contains three designed siRNAs for LRP5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LRP5 Human Pre-designed siRNA Set A LRP5 Human Pre-designed siRNA Set A

HY-RS24282

Lrp5 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lrp5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Lrp5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lrp5 Rat Pre-designed siRNA Set A Lrp5 Rat Pre-designed siRNA Set A

HY-125146

BMD4503-2	Wnt	Others
BMD4503-2 is a quinoxaline derivative with inhibitory activity against *LRP5/6-sclerostin* interactions. BMD4503-2 restores the activity of the Wnt/β-catenin signaling pathway by competitively binding to the *LRP5/6-sclerostin* complex. BMD4503-2 can be used in the study of Wnt signaling pathways in bone development, maintenance and osteoporosis .

HY-RS16292

Lrp5 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Cancer
Lrp5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lrp5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lrp5 Mouse Pre-designed siRNA Set A Lrp5 Mouse Pre-designed siRNA Set A

HY-P992263

*Anti-LRP5* Antibody**	Wnt	Inflammation/Immunology
Anti-LRP5 Antibody is a monoclonal antibody that targets LRP5. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-LRP5 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-169508

BMD4503-1	Wnt	Others
BMD4503-1 is a quinoxaline derivative. BMD4503-1 can inhibit the *LRP5/6-Sclerostin* interaction and regulate the Wnt signaling pathway .

HY-P991569

PF-04840082	Wnt	Metabolic Disease Endocrinology
PF-04840082 is a humanized IgG2 monoclonal antibody inhibitor targeting Dkk-1. PF-04840082 binds the physiological antagonist (Dkk-1) of the Wnt/LRP5 signal pathway and increases bone mass and bone mass density by activating osteoblasts. PF-04840082 can be used for osteoporosis research .

HY-E70390

C1s Enzyme masp-2, c1 esterase, c1-esterase	Wnt	Cardiovascular Disease Inflammation/Immunology
C1s Enzyme is a subunit of the complement C1 complex, which activates the complement as a serine protease. C1s Enzyme cleaves LRP5 and LRP6, and thus activates the Wnt/β-Catenin signaling pathway. C1s Enzyme promotes the macrophage M2 polarization and inhibits M1 polarization. C1s Enzyme enhances efferocytosis, exhibits anti-inflammatory activity .

HY-P992126

Remigromig EYE-103; MK-3000	Wnt	Neurological Disease
Remigromig is a humanized bispecific monoclonal antibody targeting LRP5 and FZD4, suitable for use in research related to macular degeneration .

HY-181930

TNIK-IN-10	Wnt c-Myc Apoptosis	Cancer
TNIK-IN-10 (Compound N15) is a TNIK inhibitor with an IC₅₀ of 0.49 nM against human TNIK. TNIK-IN-10 inhibits the enzymatic activity of TNIK, downregulates the expression of Wnt pathway target genes c-Myc and AXIN2, and reduces the protein expression of *LRP5* and *LRP6. TNIK-IN-10 induces apoptosis*. TNIK-IN-10 exhibits anticancer activity against colorectal cancer. TNIK-IN-10 can be used in the research of colorectal cancer .

HY-181585

FP1-24	Casein Kinase	Others
FP1-24 is a non-selective CK1 kinase inhibitor, with IC₅₀ values of 40 nM, 10 nM, 10 nM, and 40 nM against human CK1γ1, CK1γ2, CK1γ3 and CK1δ, respectively. FP1-24 exerts its activity by reducing the phosphorylation level of LRP5/6 at the T1479 site during WNT signaling pathway activation. The non-specific binding of FP1-24 to multiple kinases can be used for biological studies of specific CK1γ .

Cat. No.	Product Name	Target	Research Area	Image

HY-P992263

*Anti-LRP5* Antibody**	Wnt	Inflammation/Immunology
Anti-LRP5 Antibody is a monoclonal antibody that targets LRP5. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-LRP5 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991569

PF-04840082	Wnt	Metabolic Disease Endocrinology
PF-04840082 is a humanized IgG2 monoclonal antibody inhibitor targeting Dkk-1. PF-04840082 binds the physiological antagonist (Dkk-1) of the Wnt/LRP5 signal pathway and increases bone mass and bone mass density by activating osteoblasts. PF-04840082 can be used for osteoporosis research .

HY-P992126

Remigromig EYE-103; MK-3000	Wnt	Neurological Disease
Remigromig is a humanized bispecific monoclonal antibody targeting LRP5 and FZD4, suitable for use in research related to macular degeneration .

Species:	Human (2)
Tag:	His (1) Avi (1) Fc (1)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P78838

	LRP-5 Protein, Human (Biotinylated, HEK293, His-Avi) LRP5; LRP-5; LRP-7; LRP7; LR3	Human	HEK293
	The LRP-5 protein functions as a coreceptor, cooperating with Frizzled receptors to initiate the canonical Wnt signaling pathway. It is critical for cell fate determination and self-renewal and plays an important role in posterior ectoderm patterning during gastrulation and bone development by affecting osteoblast proliferation and differentiation. LRP-5 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived LRP-5 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of LRP-5 Protein, Human (Biotinylated, HEK293, His-Avi) is 620 a.a., with molecular weight of 70-90 kDa.

HY-P77989

	LRP-5 Protein, Human (HEK293, mFc) LRP-5; LRP-7; LR3; BMND1; BMND1OPTA1; EVR1; EVR4; HBM; LR3VBCH2; LRP5; LRP7; OPPG; OPS; OPTA1; VBCH2	Human	HEK293
	The LRP-5 protein functions as a coreceptor, cooperating with Frizzled receptors to initiate the canonical Wnt signaling pathway. It is critical for cell fate determination and self-renewal and plays an important role in posterior ectoderm patterning during gastrulation and bone development by affecting osteoblast proliferation and differentiation. LRP-5 Protein, Human (HEK293, mFc) is the recombinant human-derived LRP-5 protein, expressed by HEK293 , with C-mFc labeled tag.

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LRP5 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
LRP5 Human Pre-designed siRNA Set A contains three designed siRNAs for LRP5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lrp5 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Lrp5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Lrp5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lrp5 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Lrp5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lrp5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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