524-26-5
Chemical Structure
Gallocyanine
Synonym(s): NCI8642
- CAS No.: 524-26-5
- Formula:C15H12N2O5
- Molecular Weight:300.27
IUPAC Name: 7-(dimethylamino)-4-hydroxy-3-oxo-3H-phenoxazine-1-carboxylic acid
InChIKey: YBGOLOJQJWLUQP-UHFFFAOYSA-N
SMILES: O=C(C1=CC(C(O)=C2OC3=C(N=C21)C=CC(N(C)C)=C3)=O)O
Biological Activity: Gallocyanine (NCI8642) is a DKK/LRP interaction inhibitor and Wnt/β-catenin signaling pathway activator. Gallocyanine binds to the YWTD repeat domains of LRP5/6, competitively blocks the interaction between DKK and LRP5/6, with an IC50 of approximately 3 μM for inhibiting DKK1 binding to LRP5, an IC50 of 6.38 μM for inhibiting DKK1 binding to LRP6, and a Ki of 14 μM for inhibiting the DKK2C/LRP6-E3E4 interaction. Gallocyanine reverses the inhibitory effect of DKK1 on WNT3A signaling, with an EC50 of approximately 5 μM. Gallocyanine can be used in studies related to Alzheimer's disease, bone formation and glucose metabolism[1].
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Gallocyanine | Gallocyanine (NCI8642) is a DKK/LRP interaction inhibitor and Wnt/β-catenin signaling pathway activator. Gallocyanine binds to the YWTD repeat domains of LRP5/6, competitively blocks the interaction between DKK and LRP5/6, with an IC50 of approximately 3 μM for inhibiting DKK1 binding to LRP5, an IC50 of 6.38 μM for inhibiting DKK1 binding to LRP6, and a Ki of 14 μM for inhibiting the DKK2C/LRP6-E3E4 interaction. Gallocyanine reverses the inhibitory effect of DKK1 on WNT3A signaling, with an EC50 of approximately 5 μM. Gallocyanine can be used in studies related to Alzheimer's disease, bone formation and glucose metabolism. | |||||||||||||||||||||
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