LRP-5 Protein, Human (Biotinylated, HEK293, His-Avi)

LRP-5 protein acts as a pivotal coreceptor, partnering with the frizzled family of seven-transmembrane spanning receptors to transduce signals initiated by Wnt proteins. This activation leads to the canonical Wnt signaling pathway, a critical regulator of cell fate determination and self-renewal during both embryonic development and adult tissue regeneration. LRP-5 is particularly implicated in the posterior patterning of the epiblast during gastrulation and plays a crucial role in bone development by regulating osteoblast proliferation and differentiation. Mechanistically, LRP-5 facilitates the formation of the signaling complex between Wnt ligands, frizzled receptors, and itself, leading to the recruitment of AXIN1. This stabilizes beta-catenin/CTNNB1 and activates TCF/LEF-mediated transcriptional programs. Moreover, LRP-5 serves as a coreceptor for non-Wnt proteins, such as norrin/NDP, with a demonstrated role in retinal vascular development. The interaction with various partners, including FZD8, AXIN1, DKK1, MESD, KREMEN2, CSNK1E, SOST, APCDD1, and CAPRIN2, highlights its intricate involvement in the regulation of diverse cellular processes.