1403557-08-3
Chemical Structure
FP1-24
- CAS No.: 1403557-08-3
- Formula:C20H17F2N3O3
- Molecular Weight:385.36
InChIKey: GMIKNOQZLHKCFH-UHFFFAOYSA-N
SMILES: COC1=CN=C(COC2=CC=C(F)C(F)=C2)C=C1C(N3)=CC4=C3CCNC4=O
Biological Activity: FP1-24 is a non-selective CK1 kinase inhibitor, with IC50 values of 40 nM, 10 nM, 10 nM, and 40 nM against human CK1γ1, CK1γ2, CK1γ3 and CK1δ, respectively. FP1-24 exerts its activity by reducing the phosphorylation level of LRP5/6 at the T1479 site during WNT signaling pathway activation. The non-specific binding of FP1-24 to multiple kinases can be used for biological studies of specific CK1γ[1].
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FP1-24 | FP1-24 is a non-selective CK1 kinase inhibitor, with IC50 values of 40 nM, 10 nM, 10 nM, and 40 nM against human CK1γ1, CK1γ2, CK1γ3 and CK1δ, respectively. FP1-24 exerts its activity by reducing the phosphorylation level of LRP5/6 at the T1479 site during WNT signaling pathway activation. The non-specific binding of FP1-24 to multiple kinases can be used for biological studies of specific CK1γ. | |||||||||||||||||||||
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Keywords
