3112758-72-9
Chemical Structure
TNIK-IN-10
- CAS No.: 3112758-72-9
- Formula:C28H27N5O2
- Molecular Weight:465.55
InChIKey: QACPRWHARPBOTN-UHFFFAOYSA-N
SMILES: CC(C)NCCN(CCO1)C(C(C1=C2)=CC=C2C3=CN=C(NC=C4C5=CC(C#N)=CC=C5)C4=C3)=O
Biological Activity: TNIK-IN-10 (Compound N15) is a TNIK inhibitor with an IC50 of 0.49 nM against human TNIK. TNIK-IN-10 inhibits the enzymatic activity of TNIK, downregulates the expression of Wnt pathway target genes c-Myc and AXIN2, and reduces the protein expression of LRP5 and LRP6. TNIK-IN-10 induces apoptosis. TNIK-IN-10 exhibits anticancer activity against colorectal cancer. TNIK-IN-10 can be used in the research of colorectal cancer[1].
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TNIK-IN-10 | TNIK-IN-10 (Compound N15) is a TNIK inhibitor with an IC50 of 0.49 nM against human TNIK. TNIK-IN-10 inhibits the enzymatic activity of TNIK, downregulates the expression of Wnt pathway target genes c-Myc and AXIN2, and reduces the protein expression of LRP5 and LRP6. TNIK-IN-10 induces apoptosis. TNIK-IN-10 exhibits anticancer activity against colorectal cancer. TNIK-IN-10 can be used in the research of colorectal cancer. | |||||||||||||||||||||
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Keywords
