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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
Mark4
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "Mark4" in MCE Product Catalog:
3
3 Cited Publications
PCC0208017 is a microtubule affinity regulating kinases (MARK3/MARK4) inhibitor with IC50s of 1.8 and 2.01 nM, respectively. PCC0208017 has much lower inhibitory activity against MARK1 and MARK2, with IC50s of 31.4 and 33.7 nM, respectively. PCC0208017 suppresses glioma progression in vitro and in vivo. PCC0208017 disrupts microtubule dynamics and induces G2/M phase cell cycle arrest and cell apoptosis. PCC0208017 demonstrates robust antitumor activity in vivo and displays good BBB permeability .
1
1 Cited Publications
MARK4 inhibitor 1 is a potent and selective microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM. MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis .
FMF-06-098-1 is a multi-target kinase PROTAC degrader. FMF-06-098-1 can be used to target degradation kinases which degrades AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1 .
Target:
PROTACs CDK AAK1 Cyclin G-associated Kinase (GAK) Salt-inducible Kinase (SIK) LIM Kinase (LIMK) Wee1 SnRK
研究分野:
RSS0680 is a small noncoding RNA (sRNA) targeting the mRNA ribosome binding site (RBS) and a PROTAC. RSS0680 competitively binds to RBS through the conserved CCUCCUCCC anti-Shine-Dalgarno (aSD) sequence and inhibits the translation initiation of target genes. RSS0680 can interact with the DUF1127 protein CcaF1, regulate its own stability and participate in bacterial oxidative stress defense, enhancing the host's resistance to heat shock and oxidative damage by affecting pathways such as C1 metabolism and pyruvate dehydrogenase complex. RSS0680 degrades AAK1, CDK1, CDK16, CDK2, CDK4, CDK6, EIF2AK4, GAK, LATSl, LIMK2, MAPK6, MAPKAPK5, MARK2, MARK4, MKNK2, NEK9, RPS6KB1, SIK2, SNRK, STK17A, STK17B, STK35, and WEEl. RSS0680 can be used to study diseases or disorders mediated by aberrant kinase activity and regulatory mechanisms of noncoding RNAs in α-proteobacteria[1][2].
製品番号: HY-154988
純度: 99.23%
Target:
研究分野:
MARK4 inhibitor 4 is a MARK4 inhibitor with an IC50 of 1.49 μM. MARK4 inhibitor 4 can be used in cancer and tau lesion-related research .
製品番号: HY-RS08152
Target:
研究分野:
MARK4 Human Pre-designed siRNA Set A contains three designed siRNAs for MARK4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS18182
Target:
研究分野:
Mark4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mark4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS24656
Target:
研究分野:
Mark4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mark4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-P701808
純度: ≥ 90%, as determined by reducing SDS-PAGE.
別名: Mark4; FLJ90097; Prev. MarkL1; Non-Specific Serine/Threonine Protein Kinase; MAP/Microtubule Affinity-Regulating Kinase 4; Epididymis Secretory Sperm Binding Protein; KIAA1860; Mark4 Serine/Threonine Protein Kinase; PAR-1D; MarkL1L; MAP/Microtubule Affini
製品番号: HY-P706073
純度: ≥ 85%, as determined by reducing SDS-PAGE.
別名: Mark4; FLJ90097; Prev. MarkL1; Non-Specific Serine/Threonine Protein Kinase; MAP/Microtubule Affinity-Regulating Kinase 4; Epididymis Secretory Sperm Binding Protein; KIAA1860; Mark4 Serine/Threonine Protein Kinase; PAR-1D; MarkL1L; MAP/Microtubule Affini
Species:
Source:
製品番号: HY-P701809
純度: ≥ 90%, as determined by reducing SDS-PAGE.
別名: Mark4; FLJ90097; Prev. MarkL1; Non-Specific Serine/Threonine Protein Kinase; MAP/Microtubule Affinity-Regulating Kinase 4; Epididymis Secretory Sperm Binding Protein; KIAA1860; Mark4 Serine/Threonine Protein Kinase; PAR-1D; MarkL1L; MAP/Microtubule Affinity-Regulating Kinase Like 1; Mark4L; Nbla00650; Mark4S; Microtubule Affinity Regulating Kinase 4; MAP/Microtubule Affinity-Regulating Kinase-Like 1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
