MARK4 inhibitor 3
Based on 1 Customer Validation
MARK4 inhibitor 3 (compound 23b) is an inhibitor of MARK4 with an IC50 value of 1.01 μM. MARK4 inhibitor 3 inhibits cancer cells growth. MARK4 inhibitor 3 can be used for research on cancer and tauopathies.
For research use only. We do not sell to patients.
- Purity: 98.23%
- Formula: C33H27FN4O3
- Molecular Weight:546.59
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Microtubule affinity-regulating kinase 4 (MARK4)[1] IC50:1.01 μM (Microtubule affinity-regulating kinase 4, MARK4)[1]
MARK4 inhibitor 3 (1-20 μM, 24 h) inhibits Hela and U87MG growth with EC50 values of 2.52 μM and 4.22 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Hela, U87MG
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Concentration:1-20 μM
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Incubation Time:24 h
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Result:Inhibited cell growth with EC50 values of 2.52 μM (Hela), 4.22 μM (U87MG).
Chemical Information
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Appearance Solid
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Molecular Weight 546.59
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Formula C33H27FN4O3
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Color Off-white to light yellow
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SMILES
O=C(NC1=CC=C(F)C=C1)[C@@H](NC(CN(C2=C3C=CC=C2)C4=CC=C(C)C=C4C3=O)=O)CC5=CNC6=C5C=CC=C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (228.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8295 mL | 9.1476 mL | 18.2952 mL | 45.7381 mL |
| 5 mM | 0.3659 mL | 1.8295 mL | 3.6590 mL | 9.1476 mL | |
| 10 mM | 0.1830 mL | 0.9148 mL | 1.8295 mL | 4.5738 mL | |
| 15 mM | 0.1220 mL | 0.6098 mL | 1.2197 mL | 3.0492 mL | |
| 20 mM | 0.0915 mL | 0.4574 mL | 0.9148 mL | 2.2869 mL | |
| 25 mM | 0.0732 mL | 0.3659 mL | 0.7318 mL | 1.8295 mL | |
| 30 mM | 0.0610 mL | 0.3049 mL | 0.6098 mL | 1.5246 mL | |
| 40 mM | 0.0457 mL | 0.2287 mL | 0.4574 mL | 1.1435 mL | |
| 50 mM | 0.0366 mL | 0.1830 mL | 0.3659 mL | 0.9148 mL | |
| 60 mM | 0.0305 mL | 0.1525 mL | 0.3049 mL | 0.7623 mL | |
| 80 mM | 0.0229 mL | 0.1143 mL | 0.2287 mL | 0.5717 mL | |
| 100 mM | 0.0183 mL | 0.0915 mL | 0.1830 mL | 0.4574 mL |
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