MARK4 inhibitor 1
Based on 1 publication(s) in Google Scholar
MARK4 inhibitor 1 is a potent and selective microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM. MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis.
For research use only. We do not sell to patients.
- Purity: 98.29%
- CAS No.: 2271081-58-2
- Formula: C20H18N6O3
- Molecular Weight:390.40
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MARK4 inhibitor 1
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Biological Activity
IC50: 1.54 μM (MARK4)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
200 μM
Compound: 9g
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Antiproliferative activity against human HEK293 cells assessed as cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HEK293 cells assessed as cell viability after 48 hrs by MTT assay
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[PMID: 30579124] |
| HepG2 | IC50 |
8.14 μM
Compound: 9g
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Antiproliferative activity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay
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[PMID: 30579124] |
| MCF7 | IC50 |
6.22 μM
Compound: 9g
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Antiproliferative activity against human MCF7 cells assessed as cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell viability after 48 hrs by MTT assay
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[PMID: 30579124] |
| MDA-MB-435S | IC50 |
9.94 μM
Compound: 9g
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Antiproliferative activity against human MDA-MB-435S cells assessed as cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-435S cells assessed as cell viability after 48 hrs by MTT assay
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[PMID: 30579124] |
MARK4 inhibitor 1 (compound 9g; 0-200 µM ; 24-48 h) shows inhibition of cell proliferation and cell migration[1].
MARK4 inhibitor 1 (compound 9g; 24) induces apoptosis in these cancerous cells, with IC50 values of 6.22 μM, 9.94 μM and 8.14 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7, MDA-MB-435s and HepG2 cells
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Concentration:0-200 µM
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Incubation Time:24 and 48 h
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Result:Decreased the viability of these cells in a concentration dependent manner.
Chemical Information
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CAS No. 2271081-58-2
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Appearance Solid
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Molecular Weight 390.40
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Formula C20H18N6O3
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Color Light yellow to yellow
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SMILES
O=C(C1=CN(CC2=CC=C(OC)C=C2)N=N1)N/N=C3C(NC4=C/3C=CC=C4C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Mater Today Bio
Nanotube topography inhibits NLRP3 inflammasome activation by reducing microtubule glutamylation. [Abstract]2025 May 10:32:101838. PMID: 40487178
Solvent & Solubility
DMSO : 5 mg/mL (12.81 mM; ultrasonic and adjust pH to 2 with HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5615 mL | 12.8074 mL | 25.6148 mL | 64.0369 mL |
| 5 mM | 0.5123 mL | 2.5615 mL | 5.1230 mL | 12.8074 mL | |
| 10 mM | 0.2561 mL | 1.2807 mL | 2.5615 mL | 6.4037 mL |
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