2 Results for "

Mycobacterium tuberculosis ClpC2

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Mycobacterium tuberculosis ClpC2" in MCE Product Catalog:

  • Targets Recommended:
Cyclomarin A
Cyclomarin A
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Cat. No.: HY-P6300
CAS No.: 169062-92-4
Target:  

Bacterial Parasite

Research Areas:  

Infection

Cyclomarin A is an antibacterial agent with a Kd of 2.3 nM against Mycobacterium tuberculosis ClpC1, a Kd of 2.2 nM against ClpC2, and an IC50 of 0.004 μM against Plasmodium falciparum PfAp3Aase. Cyclomarin A binds to the N-terminal domain of ClpC1, stimulates ATPase and proteolytic activities, dysregulates proteolysis, and induces proteome imbalance; it also binds to ClpC2 and upregulates its transcription level. Cyclomarin A binds to PfAp3Aase in dimeric form, blocks the substrate-binding pathway, inhibits the growth of Plasmodium falciparum in the erythrocytic stage, and shows no activity against human cells. Cyclomarin A exhibits moderate cytotoxicity against a variety of cancer cell lines. Cyclomarin A can serve as a lead compound for the development of Homo-BacPROTAC. Cyclomarin A is applicable to research related to tuberculosis and malaria .
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SRG-II-19F
SRG-II-19F
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Cat. No.: HY-153573
Synonyms: dCym-JQ1
Target:  

PROTACs Epigenetic Reader Domain Bacterial

Research Areas:  

Infection

SRG-II-19F (dCym-JQ1) is a BRDTBD1 PROTAC degrader. Its dCym moiety at one end binds to the N-terminal domain of ClpC1 (ClpC1NTD), while its JQ1 moiety at the other end binds to bromodomain 1 of BRDT (BRDTBD1). This molecule induces the degradation of BRDTBD1 by recruiting the BRDTBD1 substrate to the ClpC1P1P2 protease complex. SRG-II-19F serves as a research tool for studies related to mycobacterial protein degradation .
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