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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
Nrf1
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "Nrf1" in MCE Product Catalog:
3
3 Cited Publications
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WRR139 is a peptide vinyl sulfone involving in disease processes such as inflammation and cancer. WRR139 is also a cytosolic enzyme N-glycanase 1 (NGLY1) and Nrf1 inhibitor. WRR139 enhances Carfilzomib cytotoxicity against cancer cells [1].
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1 Cited Publications
Cat. No.: HY-P80769
Synonyms: alpha pal; alpha palindromic binding protein; Alpha palindromic-binding protein; Alpha-pal; locus control region factor 1; NFE2 related factor 1; Nrf-1; Nrf1; Nrf1_HUMAN; Nuclear respiratory factor 1; transcription factor 11.
Synonyms: ASC-JM17; ALZ-003
Target:
Keap1-Nrf2 Androgen Receptor HSP Mitophagy Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Autophagy
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Rosolutamide (ASC-JM17) is an orally active Nrf1/Nrf2 activator. Rosolutamide activates Hsf1 pathways, upregulates proteasome subunits and antioxidant enzymes, induces proteasome complex structural rearrangement, and enhances ubiquitin-proteasome system-mediated degradation. Rosolutamide reduces mutant androgen receptor and ataxin-3 aggregates, restores mitochondrial function, attenuates reactive oxygen species (ROS) levels, induces apoptosis and ferroptosis, and inhibits cancer cell growth. Rosolutamide can be used for the research of spinal and bulbar muscular atrophy, Huntington’s disease, and temozolomide-resistant glioblastoma [1] .
Cat. No.: HY-RS09567
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NRF1 Human Pre-designed siRNA Set A contains three designed siRNAs for NRF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17333
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Nrf1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nrf1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23788
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Nrf1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nrf1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-125535
CAS No.: 1290069-19-0
OSU-53 is an orally active AMPK activator (EC50: 0.3 μM) and a direct mTOR inhibitor. OSU-53 induces autophagy and increases conversion of LC3 I to LC3 II. OSU-53 also modulates energy homeostasis by suppressing fatty acid biosynthesis and shifting the metabolism to oxidation by up-regulating the expression of PGC1α and NRF-1. OSU-53 has antitumor activity in various tumor models, such as breast cancer and thyroid cancer [1] .
Cat. No.: HY-P85571
Synonyms: alpha pal; alpha palindromic binding protein; Alpha palindromic-binding protein; Alpha-pal; locus control region factor 1; NFE2 related factor 1; Nrf-1; Nrf1; Nrf1_HUMAN; Nuclear respiratory factor 1; transcription factor 11.
Cat. No.: HY-RS09244
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NFE2L1 Human Pre-designed siRNA Set A contains three designed siRNAs for NFE2L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P80769A
Synonyms: alpha pal; alpha palindromic binding protein; Alpha palindromic-binding protein; Alpha-pal; locus control region factor 1; NFE2 related factor 1; Nrf-1; Nrf1; Nrf1_HUMAN; Nuclear respiratory factor 1; transcription factor 11.
Cat. No.: HY-RS21165
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Nfe2l1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nfe2l1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P87347
Synonyms: erythroid derived 2 antibody; like 1 antibody; Locus control region factor 1 antibody; Locus control region-factor 1 antibody; NF-E2-related factor 1 antibody; NF2L1_HUMAN antibody; NFE2 related factor 1 antibody; NFE2-related factor 1 antibody; NFE2L1 antibody; Nrf1 antibody
Cat. No.: HY-184160
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Research Areas:
Mcl1 Degrader-1 is an autophagy-targeting chimera (AUTAC) that selectively degrades the Mcl1 protein. Mcl1 Degrader-1 mediates K63 ubiquitination of Mcl1 via TRAF6/UBC13, transports it to autolysosomes for degradation through p62/SQSTM1, and activates Beclin1-dependent autophagy. Mcl1 Degrader-1 can be used in studies related to multiple myeloma and non-small cell lung cancer [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
