16 Results for "

P1363

" in MedChemExpress (MCE) Product Catalog:
Products (16)

16 Results for "P1363" in MCE Product Catalog:

27
β-Amyloid (1-42), human, HFIP-treated
β-Amyloid (1-42), human, HFIP-treated
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27 Publications Verification
Cat. No.: HY-P1363B
CAS No.: 107761-42-2
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

β-Amyloid (1-42), human, HFIP-treated, a 42-amino acid peptide that has been treated with HFIP from β-Amyloid (1-42), human (HY-P1363A), is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human, HFIP-treated remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, HFIP-treated, after being dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4°C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37°C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .
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27
β-Amyloid (1-42), human TFA
β-Amyloid (1-42), human TFA
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27 Publications Verification
Cat. No.: HY-P1363
Synonyms: Amyloid β-peptide (1-42) (human) TFA
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

β-Amyloid (1-42) (Amyloid β-peptide (1-42), human TFA, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human TFA remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human TFA, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .
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27
β-Amyloid (1-42), human
β-Amyloid (1-42), human
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27 Publications Verification
Cat. No.: HY-P1363A
CAS No.: 107761-42-2
Synonyms: Amyloid β-peptide (1-42) (human)
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

β-Amyloid (1-42) (Amyloid β-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .
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5-FAM-β-Amyloid (1-42), human Tris
5-FAM-β-Amyloid (1-42), human Tris
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Cat. No.: HY-P1363F3
Synonyms: 5-FAM-Amyloid β-peptide (1-42) (human) Tris
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

5-FAM-β-Amyloid (1-42), human (5-FAM-Amyloid β-peptide (1-42) (human) Tris is a 5-FAM labeled β-Amyloid (1-42), human. β-Amyloid (1-42), human is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome.
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Biotin-β-Amyloid (1-42), human TFA
Biotin-β-Amyloid (1-42), human TFA
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Cat. No.: HY-P1363F1
Synonyms: Biotin-amyloid β-peptide (1-42) (human) TFA
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Biotin-β-Amyloid (1-42), human TFA (Biotin-Amyloid β-Peptide (1-42) (human) TFA) is the botin labeled β-Amyloid (1-42), human TFA (HY-P1363). β-Amyloid (1-42), human TFA is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease .
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β-Amyloid-15N (1-42), human TFA
β-Amyloid-15N (1-42), human TFA
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Cat. No.: HY-P1363S
Synonyms: Amyloid β-peptide-15N (1-42) (human) TFA
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

β-Amyloid- 15N (1-42), human (TFA) is the 15N-labledβ-Amyloid (1-42) (TFA). β-Amyloid (1-42), human TFA (Amyloid β-Peptide (1-42) (human) TFA) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease .
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β-Amyloid (1-42), human, Ala(13C3,15N) TFA
β-Amyloid (1-42), human, Ala(13C3,15N) TFA
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Cat. No.: HY-P1363S1
Target:  

Isotope-Labeled Compounds Amyloid-β

Research Areas:  

Neurological Disease

β-Amyloid (1-42), human, Ala( 13C3, 15N) TFA is the 13C and 15N-labeled β-Amyloid (1-42), human (HY-P1363A). β-Amyloid (1-42) (Amyloid β-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .
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Cys-β-Amyloid (1-42), human
Cys-β-Amyloid (1-42), human
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Cat. No.: HY-P1363D
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Cys-β-Amyloid (1-42), human is a Cys-labeled β-Amyloid (1-42), human TFA (HY-P1363). β-Amyloid (1-42), human TFA is a peptide composed of 42 amino acids that plays a key role in the pathogenesis of Alzheimer's disease.
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β Amyloid (1-42) (scrambled) TFA
β Amyloid (1-42) (scrambled) TFA
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Cat. No.: HY-P4867A
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

β Amyloid (1-42) (scrambled) TFA is a negative control of β-Amyloid (1-42), human TFA (HY-P1363) .
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Citrullinated amyloid-β (1-42) peptide (human)
Citrullinated amyloid-β (1-42) peptide (human)
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Cat. No.: HY-P5905
Synonyms: Citrullinated Aβ (1-42); Citrullinated Aβ42
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Citrullinated amyloid-β (1-42) peptide (human) (Citrullinated Aβ (1-42)) is a modified form of β-Amyloid (1-42) (HY-P1363) with a citrullination at the Arg5 site. Compared to the unmodified β-Amyloid (1-42), its formation of soluble low-molecular-weight oligomers is enhanced, the rate of fibril formation is reduced, and like unmodified Aβ42, it forms protofibrils comprised of parallel β-sheets .
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β Amyloid (1-42) (scrambled)
β Amyloid (1-42) (scrambled)
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Cat. No.: HY-P4867
CAS No.: 1678415-52-5
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

β Amyloid (1-42) (scrambled) is a negative control of β-Amyloid (1-42), human (HY-P1363A) .
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Biotinyl-Ahx-Amyloid β-Protein (1-42)
Biotinyl-Ahx-Amyloid β-Protein (1-42)
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Cat. No.: HY-P4861
CAS No.: 1872440-40-8
Target:  

Amyloid-β

Research Areas:  

Others

Biotinyl-Ahx-Amyloid β-Protein (1-42) is abiotinylated β-Amyloid (1-42), human (TFA) (HY-P1363).
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(Gln22)-Amyloid β-Protein (1-42)
(Gln22)-Amyloid β-Protein (1-42)
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Cat. No.: HY-P4585
CAS No.: 147335-12-4
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

(Gln22)-Amyloid β-Protein (1-42) is a Dutch mutation (E22Q) form of β-Amyloid (1-42) (HY-P1363). (Gln22)-Amyloid β-Protein (1-42) exhibits enhanced fibrillogenic and pathogenic properties .
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Biotinyl-Amyloid β-Protein (1-42) ammonium
Biotinyl-Amyloid β-Protein (1-42) ammonium
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Cat. No.: HY-P3860
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Biotinyl-Amyloid β-Protein (1-42) ammonium is a biotinylated Amyloid β-Protein (1-42) (HY-P1363). Biotinyl-Amyloid β-Protein (1-42) ammonium can be used for the research of Aβ1-42 converts to Aβ1-40 in brain .
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RI-OR2
RI-OR2
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Cat. No.: HY-P10823
CAS No.: 1219627-58-3
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

RI-OR2, a retro-inverso peptide, is an amyloid-β (Aβ) oligomerization inhibitor. RI-OR2 binds to immobilized β-Amyloid (1-42) (HY-P1363A) monomers and fibrils, with an apparent Kd of 9-12 μM, and also acted as an inhibitor of Aβ(1-42) fibril extension .
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Schisandrastemoside A
Schisandrastemoside A
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Cat. No.: HY-N7999
CAS No.: 2014382-50-2
Category:  

Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Saccharides Monosaccharides

Target:  

Others

Schisandrastemoside A (Compound 3) is a lignan found in the rattan stems of Schisandra chinensis. Schisandrastemoside A shows neuroprotective efect and protects cells against Amyloid-beta 1-42 (HY-P1363A)-induced neurotoxicity. Schisandrastemoside A can be used for the research of Alzheimer's disease .
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