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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
RBX1
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "RBX1" in MCE Product Catalog:
26
Research Areas:
Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate.
5
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E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a molecular glue that induces the targeted degradation of splicing factor RBM39 by recruiting the E3 ubiquitin ligase CUL4-RBX1-DDB1-DCAF15 (CRL4 DCAF15). E7820 is an angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. E7820 inhibits rat aorta angiogenesis with an IC50 of 0.11 μg/ml. E7820 modulates α-1, α-2, α-3, and α-5 integrin mRNA expression. E7820 can be used for the study of acute myeloid leukemia (AML) [1] .
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2 Cited Publications
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BETd-246 is a BRD2/3/4 PROTAC degrader targeting the BET family. BETd-246 induces ubiquitination and proteasomal degradation of BRD2, BRD3 and BRD4 by recruiting the CUL4-RBX1-DDB1-CRBN E3 ubiquitin ligase complex; it also inhibits TRAT1 expression and depletes BET proteins. BETd-246 suppresses cancer cell proliferation and invasion, disrupts the cell cycle and induces apoptosis. BETd-246 is applicable to research related to triple-negative breast cancer and T-cell acute lymphoblastic leukemia [1] .
Cat. No.: HY-RS11776
Target:
Research Areas:
RBX1 Human Pre-designed siRNA Set A contains three designed siRNAs for RBX1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Research Areas:
Thalidomide (Standard) is the analytical standard of Thalidomide. This product is intended for research and analytical applications. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate.
Cat. No.: HY-RS24625
Target:
Research Areas:
Rbx1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Rbx1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-14658S
CAS No.: 1219177-18-0
Cat. No.: HY-RS18150
Target:
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Rbx1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rbx1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-162240
Target:
Research Areas:
SJH1-51B is a SKP1-recruiting BRD4 PROTAC degrader. SJH1-51B binds to SKP1 in the SKP1-FBXO7-CUL1-RBX1 complex, but shows no or weak binding to monomeric SKP1. SJH1-51B induces proteasome- and SKP1-dependent degradation of BRD4, and this degradation process relies on the neddylation modification of Cullin-RING E3 ligase. SJH1-51B induces proteasome-mediated degradation of the short isoform of BRD4 in non-cancer cells, while it induces proteasome-mediated degradation of both the long and short isoforms of BRD4 in breast cancer cells. SJH1-51B can be used for breast cancer research [1].
Cat. No.: HY-182063
CAS No.: 2419496-02-7
Target:
Research Areas:
Z226407860 is a RING-box protein 1 (RBX1) inhibitor. Z226407860 reduces house dust mite-induced airway epithelial injury and ROS accumulation by inhibiting RBX1. Z226407860 can be used for the research of asthma [1].
Cat. No.: HY-P81379A
Synonyms: ROC1; RNF75; RBX1; E3 ubiquitin-protein ligase RBX1; RING finger protein 75; RING-box protein 1 (RBX1)
Cat. No.: HY-P87951
Synonyms: RNF75, ROC1, RBX1, E3 ubiquitin-protein ligase RBX1, E3 ubiquitin-protein transferase RBX1, Protein ZYP, RING finger protein 75, RING-box protein 1, Regulator of cullins 1, RBX1
Cat. No.: HY-P702817
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Cereblon-DDB1-Cul4A-RBX1 Complex
Cat. No.: HY-P702826
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Cereblon-DDB1-Cul4A-RBX1 Complex
Species:
Source:
Cat. No.: HY-P703237
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: VACM1
Species:
Source:
Cat. No.: HY-P703245
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KIAA0617; Cullin-4A
Species:
Source:
Cat. No.: HY-P703559
Purity: ≥ 95%, as determined by reducing SDS-PAGE
Synonyms: C4orf30
Species:
Source:
Cat. No.: HY-P703242
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Cullin-1; CUL1; Homo sapiens; Human; CUL-1
Species:
Source:
Cat. No.: HY-P703246
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Cullin-4A; CUL4A; Homo sapiens; Human
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Source:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
