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CRBN-DDB1-CUL4A-RBX1 Complex Protein, Human (HEK293, Flag, His)

CRBN-DDB1-CUL4A-RBX1 Complex Protein, Human (HEK293, Flag, His) is the recombinant human-derived Cereblon, expressed by HEK293 , with N-6*His, N-Flag labeled tag.

For research use only. We do not sell to patients.
  • Species: Human
  • Source: HEK293
  • Storage:
    Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
  • CRBN-DDB1-CUL4A-RBX1 Complex Protein, Human (HEK293, Flag, His) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
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Biological Activity

Description

CRBN-DDB1-CUL4A-RBX1 Complex Protein, Human (HEK293, Flag, His) is the recombinant human-derived Cereblon, expressed by HEK293 , with N-6*His, N-Flag labeled tag.

Technical Parameters

  • Species Human
  • Source HEK293
  • Tag N-6*His;N-Flag
  • Accession

    Q96SW2-1 (A2-L442)&Q16531-1 (M1-H1140)&Q13619-1 (A2-A759)&P62877 (M1-H108, M5I)

  • Gene ID
    51185&1642&8451&9978
  • Synonyms

    CRBN; MRT2; Prev. MRT2A; Protein X 0001; Protein Cereblon; Cereblon; Mental Retardation, Non-Syndromic, Autosomal Recessive, 2A; DDB1; XPE-BF; Damage Specific DNA Binding Protein 1; XAP-1; DNA Damage-Binding Protein 1; XAP1; Xeroderma Pigmentosum Group E-

  • Predicted Molecular Mass

    51 kDa (Cereblon) & 128 kDa (DDB1) & 87 kDa (Cul4A) & 13 kDa (Rbx1)

  • Molecular Weight

    Approximately 60 kDa (Cereblon) & 128-130 kDa (DDB1) & 85-90 kDa (Cul4A) & 15-17 kDa (Rbx1), based on SDS-PAGE under reducing conditions.

  • Purity

    ≥ 90%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Solution

Endotoxin Level

/

Storage & Stability

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
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Biological Activity (ED50) Biological Activity (ED50)
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ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • CRBN-DDB1-CUL4A-RBX1 Complex Protein, Human (HEK293, Flag, His) Product Image