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Rhein

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By Targets:	Apoptosis (4) Autophagy (2) Bacterial (5) Bcl-2 Family (2) Biochemical Assay Reagents (1) Caspase (2) CDK (1) Phosphatase (1) Reactive Oxygen Species (ROS) (2) Reference Standards (2) TGF-beta/Smad (2)
By Research Areas:	Cancer (3) Infection (5) Inflammation/Immunology (4) Metabolic Disease (3)

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Biochemical Assay Reagents

Natural
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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0105

*Rhein* Maximum Cited Publications 17 Publications Verification Rheic Acid; Rhubarb yellow; MonoRhein	Autophagy Reactive Oxygen Species (ROS) Bacterial Apoptosis	Infection Inflammation/Immunology Cancer
Rhein is an anthraquinone compound with anti-inflammatory, antioxidant, and anti-cancer effects ^{[1] ^.}

HY-N6082

Rhein 8-O-β-D-Glucopyranoside 1 Publications Verification	Apoptosis Bcl-2 Family Caspase TGF-beta/Smad Bacterial	Infection Metabolic Disease Inflammation/Immunology
Rhein 8-O-β-D-Glucopyranoside is an orally active glycoside found in Rhubarb. Rhein 8-O-β-D-Glucopyranoside attenuates high glucose-induced apoptosis, recovers altered lincRNA ANRIL and let-7a expression, reverses high glucose-altered Bcl-2 and cleaved caspase-3 protein expression, and inhibits TGF-β1/Smad signaling. Rhein 8-O-β-D-Glucopyranoside accelerates Sennoside A (HY-N0365) metabolism, stimulates sennoside A purgative activity. Rhein 8-O-β-D-Glucopyranoside inhibits bacterial biofilm formation, suppresses its virulence gene expression, and exerts antibacterial activity. Rhein 8-O-β-D-Glucopyranoside can be used for the research of diabetic nephropathy, constipation, and infection .

HY-N0105R

Rhein (Standard) Maximum Cited Publications 17 Publications Verification Rheic Acid (Standard); Rhubarb yellow (Standard); MonoRhein (Standard)	Reference Standards Autophagy Reactive Oxygen Species (ROS) Bacterial	Infection Inflammation/Immunology Cancer
Rhein (Standard) is the analytical standard of Rhein. This product is intended for research and analytical applications.

HY-N0312

Rhein-8-glucoside calcium	Phosphatase Bacterial	Infection Metabolic Disease
Rhein-8-glucoside calcium, an anthraquinone compound, is isolated from the EtOH extract of the roots of Saussurea lappa. Rhein-8-glucoside calcium is an hPTP1B inhibitor, with an IC₅₀ of 11.5 μM. Rhein-8-glucoside calcium has antibacterial effects .

HY-N6082R

Rhein 8-O-β-D-Glucopyranoside (Standard)	Reference Standards Apoptosis Bacterial Bcl-2 Family Caspase TGF-beta/Smad	Infection Metabolic Disease Inflammation/Immunology
Rhein 8-O-β-D-Glucopyranoside (Standard) is the analytical standard of Rhein 8-O-β-D-Glucopyranoside (HY-N6083). This product is intended for research and analytical applications. Rhein 8-O-β-D-Glucopyranoside is an orally active glycoside found in Rhubarb. Rhein 8-O-β-D-Glucopyranoside attenuates high glucose-induced apoptosis, recovers altered lincRNA ANRIL and let-7a expression, reverses high glucose-altered Bcl-2 and cleaved caspase-3 protein expression, and inhibits TGF-β1/Smad signaling. Rhein 8-O-β-D-Glucopyranoside accelerates Sennoside A (HY-N0365) metabolism, stimulates sennoside A purgative activity. Rhein 8-O-β-D-Glucopyranoside inhibits bacterial biofilm formation, suppresses its virulence gene expression, and exerts antibacterial activity. Rhein 8-O-β-D-Glucopyranoside can be used for the research of diabetic nephropathy, constipation, and infection .

HY-W740133

Rhein 8-β-D-glucuronide	Biochemical Assay Reagents	Others
Rhein 8-β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

HY-N18716

Senna leaf extract	Others	Others
Senna Leaf Extract is the main raw material of Cassia angustifolia Vahl. Its main active ingredients are Sennoside A and B, and contain rhein, aloe-emodin, chrysophanol and other anthraquinones Derivatives and other glycosides.

HY-179521

CDK1-IN-8	CDK Apoptosis	Cancer
CDK1-IN-8 is a CDK1 inhibitor. CDK1-IN-8 inhibits cell migration, induces apoptosis, and arrests the cell cycle at the G2/M phase. CDK1-IN-8 leads to a significant downregulation of CDK1 protein levels in HepG2 cells. CDK1-IN-8 can be used for the study of hepatocellular carcinoma .

Cat. No.	Product Name	Type

HY-W740133

Rhein 8-β-D-glucuronide	Biochemical Assay Reagents
Rhein 8-β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

Rhein 8-β-D-glucuronide

Biochemical Assay Reagents

Rhein 8-β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

*Rhein* Maximum Cited Publications 17 Publications Verification Rheic Acid; Rhubarb yellow; MonoRhein	Infection Quinones Rheum palmatum L. Classification of Application Fields Anthraquinones Polygonaceae Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Autophagy Reactive Oxygen Species (ROS) Bacterial Apoptosis
Rhein is an anthraquinone compound with anti-inflammatory, antioxidant, and anti-cancer effects ^{[1] ^.}

Rhein 8-O-β-D-Glucopyranoside 1 Publications Verification	Quinones Structural Classification Monophenols Rheum palmatum L. Classification of Application Fields Anthraquinones Polygonaceae Phenols Metabolic Disease Plants Disease Research Fields Source Classification	Apoptosis Bcl-2 Family Caspase TGF-beta/Smad Bacterial
Rhein 8-O-β-D-Glucopyranoside is an orally active glycoside found in Rhubarb. Rhein 8-O-β-D-Glucopyranoside attenuates high glucose-induced apoptosis, recovers altered lincRNA ANRIL and let-7a expression, reverses high glucose-altered Bcl-2 and cleaved caspase-3 protein expression, and inhibits TGF-β1/Smad signaling. Rhein 8-O-β-D-Glucopyranoside accelerates Sennoside A (HY-N0365) metabolism, stimulates sennoside A purgative activity. Rhein 8-O-β-D-Glucopyranoside inhibits bacterial biofilm formation, suppresses its virulence gene expression, and exerts antibacterial activity. Rhein 8-O-β-D-Glucopyranoside can be used for the research of diabetic nephropathy, constipation, and infection .

Rhein (Standard) Maximum Cited Publications 17 Publications Verification Rheic Acid (Standard); Rhubarb yellow (Standard); MonoRhein (Standard)	Infection Quinones Rheum palmatum L. Classification of Application Fields Polygonaceae Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Reference Standards Autophagy Reactive Oxygen Species (ROS) Bacterial
Rhein (Standard) is the analytical standard of Rhein. This product is intended for research and analytical applications.

Rhein-8-glucoside calcium	Quinones Monophenols Classification of Application Fields Rheum palmatum L. Anthraquinones Polygonaceae Phenols Metabolic Disease Plants Disease Research Fields Source Classification	Phosphatase Bacterial
Rhein-8-glucoside calcium, an anthraquinone compound, is isolated from the EtOH extract of the roots of Saussurea lappa. Rhein-8-glucoside calcium is an hPTP1B inhibitor, with an IC₅₀ of 11.5 μM. Rhein-8-glucoside calcium has antibacterial effects .

Rhein 8-O-β-D-Glucopyranoside (Standard)	Quinones Structural Classification Monophenols Rheum palmatum L. Anthraquinones Polygonaceae Phenols Plants Source Classification	Reference Standards Apoptosis Bacterial Bcl-2 Family Caspase TGF-beta/Smad
Rhein 8-O-β-D-Glucopyranoside (Standard) is the analytical standard of Rhein 8-O-β-D-Glucopyranoside (HY-N6083). This product is intended for research and analytical applications. Rhein 8-O-β-D-Glucopyranoside is an orally active glycoside found in Rhubarb. Rhein 8-O-β-D-Glucopyranoside attenuates high glucose-induced apoptosis, recovers altered lincRNA ANRIL and let-7a expression, reverses high glucose-altered Bcl-2 and cleaved caspase-3 protein expression, and inhibits TGF-β1/Smad signaling. Rhein 8-O-β-D-Glucopyranoside accelerates Sennoside A (HY-N0365) metabolism, stimulates sennoside A purgative activity. Rhein 8-O-β-D-Glucopyranoside inhibits bacterial biofilm formation, suppresses its virulence gene expression, and exerts antibacterial activity. Rhein 8-O-β-D-Glucopyranoside can be used for the research of diabetic nephropathy, constipation, and infection .

Senna leaf extract	Structural Classification Extract	Others
Senna Leaf Extract is the main raw material of Cassia angustifolia Vahl. Its main active ingredients are Sennoside A and B, and contain rhein, aloe-emodin, chrysophanol and other anthraquinones Derivatives and other glycosides.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Rhein

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Natural
Products