2. Cell Cycle/DNA Damage Apoptosis
  3. CDK Apoptosis
  4. CDK1-IN-8

CDK1-IN-8 is a CDK1 inhibitor. CDK1-IN-8 inhibits cell migration, induces apoptosis, and arrests the cell cycle at the G2/M phase. CDK1-IN-8 leads to a significant downregulation of CDK1 protein levels in HepG2 cells. CDK1-IN-8 can be used for the study of hepatocellular carcinoma.

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CDK1-IN-8

CDK1-IN-8 Chemical Structure

CAS No. : 3077717-99-5

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CDK1-IN-8 Related Antibodies

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Description

CDK1-IN-8 is a CDK1 inhibitor. CDK1-IN-8 inhibits cell migration, induces apoptosis, and arrests the cell cycle at the G2/M phase. CDK1-IN-8 leads to a significant downregulation of CDK1 protein levels in HepG2 cells. CDK1-IN-8 can be used for the study of hepatocellular carcinoma[1].

IC50 & Target[1]

CDK1

 

In Vitro

CDK1-IN-8 (Compound c9) shows the strongest inhibitory activity against HepG2 cells (IC50 of 11.88 μM). In normal L02 hepatocytes, the IC50 is 95.48 μM, and the selectivity index SI = 8.0[1].
CDK1-IN-8 (10-20 μM, 48 h) significantly inhibits the in vitro migration ability of HepG2 cells, suggesting that it has potential anti-tumor metastasis effects[1].
CDK1-IN-8 (0-5 μM, 48 h) induces significant, dose-dependent apoptosis in HepG2 cells[1].
CDK1-IN-8 (0-15 μM, 48 h) inhibits HepG2 cell proliferation by inducing cell cycle arrest in the G2/M phase[1].
CDK1-IN-8 (2.5-15 μM, 48 h) significantly and dose-dependently reduces the expression level of CDK1 protein in HepG2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CDK1-IN-8 Related Antibodies

Cell Migration Assay [1]

Cell Line: HepG2 cells
Concentration: 10 μM, 15 μM, 20 μM
Incubation Time: 48 h
Result: Significantly and in a dose-dependent manner inhibited the migration of HepG2 cells to the scratch area; at 20 μM, the scratch closure rate was only 3.70%.

ELISA Assay[1]

Cell Line: HepG2 cells
Concentration: 0 μM, 2.5 μM, 5 μM, 7.5 μM, 10 μM, 15 μM
Incubation Time: 48 h
Result: At a concentration of 15 μM, reduced CDK1 expression.
Molecular Weight

604.95

Formula

C28H27ClFN2O8P
CAS No.
SMILES

OC1=C2C(C(C(C=C(C(NCCNC(C3=CC(F)=C(Cl)C=C3)P(OCC)(OCC)=O)=O)C=C4O)=C4C2=O)=O)=CC=C1
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Purity & Documentation
References
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CDK1-IN-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK1-IN-83077717-99-5CDKApoptosisCyclin dependent kinaseRheinPhosphorylationCDK1 inhibitorHepatocellular carcinomaMolecular dynamics simulationCell-cycle arrestInhibitorinhibitorinhibit

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