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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
Rho Kinase 2
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "Rho Kinase 2" in MCE Product Catalog:
6
6 Cited Publications
Cat. No.: HY-18990
CAS No.: 817194-38-0
Research Areas:
GSK180736A is potent Rho-associated coiled-coil kinase 1 (ROCK1) inhibitor with an IC50 of 100 nM. GSK180736A is also a selective and ATP-competitive G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM.
Synonyms: RXC007
Zelasudil (RXC007) is an orally active, highly selective small molecule Rho-associated coiled-coil containing protein kinase 2 (ROCK2) inhibitor with anti-fibrotic efficacy. Zelasudil elicits positive immunomodulatory effects in metastatic pancreatic tumors with increase of CD8+ and CD4+ T cell infiltrate into the tumor cortex and reduction in immunosuppressive FOXP3+ regulatory T cells at the tumor border. Zelasudil is promising for research of pancreatic ductal adenocarcinoma .
Cat. No.: HY-126432
CAS No.: 1973494-17-5
Synonyms: BA-1049
Target:
Research Areas:
NRL-1049 dihydrochloride (BA-1049) is a selective and orally active rho-associated protein kinase 2 (ROCK2) inhibitor with an IC50 of 0.59 μM. NRL-1049 dihydrochloride shows selectivity for ROCK2 is 44 times that of ROCK1 (IC50 = 26 μM). NRL-1049 dihydrochloride can preserve the blood-brain barrier after acute injury .
Cat. No.: HY-103045A
CAS No.: 1941168-71-3
Research Areas:
CMPD101 hydrochloride is a novel membrane-permeable, small-molecule inhibitor of both GRK2 and GRK3 with IC50s of 18 nM and 5.4 nM, respectively. CMPD101 hydrochloride also inhibits Rho-associated kinase 2 (ROCK-2) and PKCα (IC50s =1.4 μM and 8.1 μM, respectively) .
Cat. No.: HY-P702931
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ROCK2; ROCK-II; Rho Associated Coiled-Coil Containing Protein Kinase 2; Non-Specific Serine/Threonine Protein Kinase; Rho-Associated, Coiled-Coil-Containing Protein Kinase II; Rho-Associated Protein Kinase; Rho-Associated Protein Kinase 2; Rho Kinase 2; P
Species:
Source:
Cat. No.: HY-P705689
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ROCK2; ROCK-II; Rho Associated Coiled-Coil Containing Protein Kinase 2; Non-Specific Serine/Threonine Protein Kinase; Rho-Associated, Coiled-Coil-Containing Protein Kinase II; Rho-Associated Protein Kinase; Rho-Associated Protein Kinase 2; Rho Kinase 2; P
Species:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
