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Results for "

SETDB1

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

2

Recombinant Proteins

3

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-173156
    UNC10013

    		Histone Methyltransferase Cancer
    UNC10013 is an inhibitor targeting the triple Tudor domain (3TD) of SETDB1. UNC10013 covalently binds to Cys385 of SETDB1 3TD, acts as a negative allosteric modulator of the methyltransferase domain of SETDB1, reduces the level of Akt methylation mediated by SETDB1, and blocks Tyr308 phosphorylation of Akt. UNC10013 is applicable to cancer-related research [1].
    UNC10013
  • HY-141539
    SETDB1-TTD-IN-1
    5 Publications Verification

    		 Histone Methyltransferase Cancer
    SETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive ligand of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD) that binds to TTD, with a Kd of 88 nM. SETDB1-TTD-IN-1 increases SETDB1 methyltransferase activity. SETDB1-TTD-IN-1 can be used for the research of biological functions and disease associations of SETDB1-TTD [1] .
    SETDB1-TTD-IN-1
  • HY-168992
    UNC6535

    		Histone Methyltransferase Neurological Disease Cancer
    UNC6535 is a covalent ligand targeting the SETDB1 triple Tudor domain (3TD) with negative allosteric modulator properties, with an IC50 of 3.4 μM and a Kd of 4.2 μM. UNC6535 inhibits the methyltransferase activity of recombinant SETDB1 protein lacking the 3TD domain. UNC6535 reversibly binds to the aromatic cages of both TD2 and TD3 subdomains of SETDB1 3TD simultaneously, displacing the endogenous H3K9Me2K14Ac histone tail ligand. UNC6535 can be used in research on cancer and neurodegenerative diseases [1] .
    UNC6535
  • HY-141539A
    SETDB1-TTD-IN-1 TFA
    5 Publications Verification

    		 Histone Methyltransferase Cancer
    SETDB1-TTD-IN-1 TFA is a potent, selective and endogenous binder competitive ligand of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD) that binds to TTD, with a Kd of 88 nM. SETDB1-TTD-IN-1 TFA increases SETDB1 methyltransferase activity. SETDB1-TTD-IN-1 TFA can be used for the research of biological functions and disease associations of SETDB1-TTD [1] .
    SETDB1-TTD-IN-1 TFA
  • HY-RS12748
    SETDB1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SETDB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SETDB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SETDB1 Human Pre-designed siRNA Set A
    SETDB1 Human Pre-designed siRNA Set A
  • HY-RS23131
    Setdb1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Setdb1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Setdb1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Setdb1 Rat Pre-designed siRNA Set A
    Setdb1 Rat Pre-designed siRNA Set A
  • HY-RS16697
    Setdb1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Setdb1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Setdb1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Setdb1 Mouse Pre-designed siRNA Set A
    Setdb1 Mouse Pre-designed siRNA Set A
  • HY-168992A
    UNC6535 TFA

    		Histone Methyltransferase Others
    UNC6535 TFA is a covalent ligand targeting the triple Tudor domain (3TD) of SETDB1. UNC6535 TFA reversibly binds to the aromatic cages of both TD2 and TD3 within SETDB1 3TD simultaneously, weakly inhibits the methyltransferase activity of SETDB1, and displaces the H3K9Me2K14Ac peptide from SETDB1 3TD [1].
    UNC6535 TFA
  • HY-181914
    UNC7242

    		Histone Methyltransferase Cancer
    UNC7242 is an antagonist that binds to the Tudor domains of PHF1 and PHF19, with a Kd of 1.13 μM for PHF1 and 0.64 μM for PHF19. UNC7242 fails to displace full-length PHF1 or PHF19 from H3K36me3 nucleosomes or chromatin. UNC7242 can be used in studies related to multiple myeloma, endometrial stromal sarcoma, and ossifying fibromyxoid tumor [1].
    UNC7242

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