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Results for "

SRF

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) CCR (1) CD47 (1) Interleukin Related (2) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) NTPDase (1) PAI-1 (1) Ras (10) Reference Standards (1) ROCK (1) Small Interfering RNA (siRNA) (3) TGF-beta/Smad (1) TRP Channel (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (5) Inflammation/Immunology (4) Metabolic Disease (3) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13991

CCG-1423 Maximum Cited Publications 14 Publications Verification	Ras Apoptosis	Cancer
CCG-1423 is an inhibitor of *Rho/MRTF/SRF* pathway. CCG-1423 shows activities in several cancer cells. CCG-1423 is a promising lead compound for the development of novel pharmacologic tools, and it can be used for the research of cancer and diabetes .

HY-108361

CCG-203971 2 Publications Verification	Ras	Inflammation/Immunology Cancer
CCG-203971 is a second-generation *Rho/MRTF/SRF* pathway inhibitor. CCG-203971 potently targets RhoA/C-activated SRE-luciferase (IC₅₀ =6.4 μM). CCG-203971 inhibits PC-3 cell migration with an IC₅₀ of 4.2 μM. Potential anti-metastasis Agent .

HY-P99533

Urabrelimab 1 Publications Verification SRF-231; SRF231	CD47 Interleukin Related	Cancer
Urabrelimab (SRF231) is a fully human anti-CD47 monoclonal antibody that blocks the CD47-SIRP interaction .

HY-111432

CCG-232601	Ras	Others
CCG-232601 (compound 8f) is a potent and orally active *Rho/MRTF/SRF* transcriptional pathway inhibitor. CCG-232601 inhibits the development of Bleomycin-induced dermal fibrosis in mice. CCG-232601 has the potential for the research of antifibrotic for systemic scleroderma .

HY-120855

CCG-100602 2 Publications Verification	Ras	Cardiovascular Disease
CCG-100602 is a specific inhibitor of myocardin-related transcription factor A/serum response factor (MRTF-A/SRF) signaling. CCG-100602 specifically block MRTF-A nuclear localization and thus inhibit the fibrogenic transcription factor SRF .

HY-P991061

Tagmokitug CHS-114; SRF-114	CCR	Cancer
Tagmokitug (CHS-114; SRF-114) is a fully human IgG1 antibody targeting CCR8. Tagmokitug selectively binds to human CCR8 (K_d = 502 pM) and mediates the death of CCR8-expressing cells via antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis. Tagmokitug selectively eliminates intratumoral regulatory T cells, induces tumor growth inhibition, remodels the tumor immune microenvironment, and promotes the differentiation of cytotoxic CD8 ⁺ T cell subsets. Tagmokitug can be used for the research of solid tumors .

HY-P990024

Casdozokitug SRF-388	Interleukin Related	Cancer
Casdozokitug (SRF-388) is an IgG1κ antibody targeting IL27 .

HY-P990068

Perenostobart SRF617	NTPDase	Inflammation/Immunology Cancer
Perenostobart (SRF617) is a human IgG4 antibody with inhibitory activity against CD39 ATPase. Perenostobart inhibits CD39-mediated hydrolysis of extracellular ATP to AMP, with IC₅₀ values of 1.9 nM (HEK293 OE cells), 0.7 nM (MOLP-8 cells), and 1.2 nM (RBC-lysed whole blood). Perenostobart enhances CD4 ⁺ T-cell proliferation, promotes dendritic cell maturation, and boosts inflammasome activation in macrophages in the presence of ATP. Perenostobart demonstrates significant single-agent anti-tumor efficacy in MOLP-8 and H520 xenograft models. Perenostobart can be used for the study of cancer .

HY-153078

*MRTF/SRF-IN-1*	Ras	Cancer
MRTF/SRF-IN-1 (example 41) is an inhibitor of both myocardin-related transcription factor and serum response factor (MRTF/SRF). MRTF/SRF-IN-1 can be used for research for preventing cancer and fibrosis .

HY-132187

Sphingosylphosphorylcholine	TGF-beta/Smad TRP Channel Apoptosis PAI-1	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Sphingosylphosphorylcholine is a bioactive lipid and a major component of plasma high-density lipoprotein that binds to OGR1 with a K_d of 33.3 nM. Sphingosylphosphorylcholine triggers delayed phosphorylation of Smad2, upregulates α-SMA expression, and activates TRPM3. Sphingosylphosphorylcholine reduces Apoptosis and upregulates the expression of uPA and its receptor uPA-R. Sphingosylphosphorylcholine exerts anti-apoptotic, anti-cardiac hypertrophy and pro-wound healing effects. Sphingosylphosphorylcholine induces scratching behavior in mice. Sphingosylphosphorylcholine is used in studies related to atopic dermatitis, promyelocytic leukemia, heart failure, myocardial ischemia/reperfusion injury, ovarian cancer, breast cancer, pancreatic cancer, and skin wound healing disorders in genetically impaired healing diabetes .

HY-162904

BPU17	Mitochondrial Metabolism	Cardiovascular Disease
BPU17 binds to PHB1 and causes mild defects in mitochondrial function by defects in the PHB1-PHB2 interaction. This impairment inhibits the SRF/CArG-box-dependent transcription, resulting in the suppression of epithelial-mesenchymal transition (EMT) of retinal pigment epithelial cells (RPEs). BPU17 exhibits antifibrotic activity in vivo. BPU17 is promising for research of anti-neovascular age-related macular degeneration (nAMD) agent .

HY-RS13760

SRF Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SRF Human Pre-designed siRNA Set A contains three designed siRNAs for SRF gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SRF Human Pre-designed siRNA Set A SRF Human Pre-designed siRNA Set A

HY-118748

Suprafenacine SRF	Microtubule/Tubulin	Cancer
Suprafenacine is a cell permeable, tubulin-destabilizing molecule which bind microtubules at the colchicine-binding site and inhibit polymerization. Suprafenacine can induce G2/M cell cycle arrest and apoptosis, and can be used for cancer research .

HY-130011

CCG-232964	ROCK Ras	Neurological Disease Cancer
CCG-232964 is an orally active inhibitor of *Rho/MRTF/SRF*. CCG-232964 inhibits LPA-induced CTGF gene expression .

HY-13991R

CCG-1423 (Standard)	Ras Apoptosis	Cancer
CCG-1423 (Standard) is the analytical standard of CCG-1423. This product is intended for research and analytical applications. CCG-1423 is an inhibitor of Rho/MRTF/SRF pathway. CCG-1423 shows activities in several cancer cells. CCG-1423 is a promising lead compound for the development of novel pharmacologic tools, and it can be used for the research of cancer and diabetes .

HY-162969

MRTF-A-IN-2	Ras	Cardiovascular Disease Metabolic Disease
MRTF-A-in-2 (Compound 16) is MRTF-A inhibitor. MRTF-A-in-1 can inhibit cell proliferation and induce HCC cell aging .

HY-162968

MRTF-A-IN-1	Ras	Cardiovascular Disease Metabolic Disease
MRTF-A-in-1 (Compound 14) is MRTF-A inhibitor. MRTF-A-in-1 can inhibit cell proliferation and induce HCC cell aging .

HY-RS17529

Srf Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Srf Mouse Pre-designed siRNA Set A contains three designed siRNAs for Srf gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Srf Mouse Pre-designed siRNA Set A Srf Mouse Pre-designed siRNA Set A

HY-RS23985

Srf Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Srf Rat Pre-designed siRNA Set A contains three designed siRNAs for Srf gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Srf Rat Pre-designed siRNA Set A Srf Rat Pre-designed siRNA Set A

HY-108361R

CCG-203971 (Standard)	Reference Standards Ras	Inflammation/Immunology Cancer
CCG-203971 (Standard) is the analytical standard of CCG-203971 (HY-108361). This product is intended for research and analytical applications. CCG-203971 is a second-generation Rho/MRTF/SRF pathway inhibitor. CCG-203971 potently targets RhoA/C-activated SRE-luciferase (IC₅₀ =6.4 μM). CCG-203971 inhibits PC-3 cell migration with an IC₅₀ of 4.2 μM. Potential anti-metastasis Agent .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99533

Urabrelimab 1 Publications Verification SRF-231; SRF231	CD47 Interleukin Related	Cancer
Urabrelimab (SRF231) is a fully human anti-CD47 monoclonal antibody that blocks the CD47-SIRP interaction .

HY-P991061

Tagmokitug CHS-114; SRF-114	CCR	Cancer
Tagmokitug (CHS-114; SRF-114) is a fully human IgG1 antibody targeting CCR8. Tagmokitug selectively binds to human CCR8 (K_d = 502 pM) and mediates the death of CCR8-expressing cells via antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis. Tagmokitug selectively eliminates intratumoral regulatory T cells, induces tumor growth inhibition, remodels the tumor immune microenvironment, and promotes the differentiation of cytotoxic CD8 ⁺ T cell subsets. Tagmokitug can be used for the research of solid tumors .

HY-P990024

Casdozokitug SRF-388	Interleukin Related	Cancer
Casdozokitug (SRF-388) is an IgG1κ antibody targeting IL27 .

HY-P990068

Perenostobart SRF617	NTPDase	Inflammation/Immunology Cancer
Perenostobart (SRF617) is a human IgG4 antibody with inhibitory activity against CD39 ATPase. Perenostobart inhibits CD39-mediated hydrolysis of extracellular ATP to AMP, with IC₅₀ values of 1.9 nM (HEK293 OE cells), 0.7 nM (MOLP-8 cells), and 1.2 nM (RBC-lysed whole blood). Perenostobart enhances CD4 ⁺ T-cell proliferation, promotes dendritic cell maturation, and boosts inflammasome activation in macrophages in the presence of ATP. Perenostobart demonstrates significant single-agent anti-tumor efficacy in MOLP-8 and H520 xenograft models. Perenostobart can be used for the study of cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-132187

Sphingosylphosphorylcholine	Structural Classification Natural Products Endogenous metabolite Source Classification	TGF-beta/Smad TRP Channel Apoptosis PAI-1
Sphingosylphosphorylcholine is a bioactive lipid and a major component of plasma high-density lipoprotein that binds to OGR1 with a K_d of 33.3 nM. Sphingosylphosphorylcholine triggers delayed phosphorylation of Smad2, upregulates α-SMA expression, and activates TRPM3. Sphingosylphosphorylcholine reduces Apoptosis and upregulates the expression of uPA and its receptor uPA-R. Sphingosylphosphorylcholine exerts anti-apoptotic, anti-cardiac hypertrophy and pro-wound healing effects. Sphingosylphosphorylcholine induces scratching behavior in mice. Sphingosylphosphorylcholine is used in studies related to atopic dermatitis, promyelocytic leukemia, heart failure, myocardial ischemia/reperfusion injury, ovarian cancer, breast cancer, pancreatic cancer, and skin wound healing disorders in genetically impaired healing diabetes .

Host:	Rabbit (3)
Reactivity:	Human (3) Rat (1) Mouse (1)
Application:	IHC-P (3) ICC/IF (3) IP (1) IHC-F (2) WB (3) FC (1)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P87085

	SRF Antibody (YA6778) c fos serum response element binding factor antibody; c fos serum response element binding transcription factor antibody; ELK3 antibody; ERP antibody; MCM 1 antibody; MCM1 antibody; OTTHUMP00000039820 antibody; SAP2 antibody; Serum response factor antibody; SRF antibody; c fos serum response element binding factor antibody; c fos serum response element binding transcription factor antibody; ELK3 antibody; ERP antibody; MCM 1 antibody; MCM1 antibody; OTTHUMP00000039820 antibody; SAP2 antibody; Serum response factor antibody; SRF antibody; SRF serum response factor c fos serum response element binding transcription factor antibody; SRF_HUMAN antibody;	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse, Rat
	SRF Antibody (YA6778) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SRF.

HY-P83523

	General Transcription Factor II I Antibody (YA3268) GTF2I; BAP135; WBSCR6; General transcription factor II-I; GTFII-I; TFII-I; Bruton tyrosine kinase-associated protein 135; BAP-135; BTK-associated protein 135; SRF-Phox1-interacting protein; SPIN; Williams-Beuren syndrome chromosomal region	WB, IHC-F, IHC-P, ICC/IF	Human
	General Transcription Factor II I Antibody (YA3268) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to General Transcription Factor II I.

HY-P83523A

	General Transcription Factor II I Antibody (YA3268)(PBS only) GTF2I; BAP135; WBSCR6; General transcription factor II-I; GTFII-I; TFII-I; Bruton tyrosine kinase-associated protein 135; BAP-135; BTK-associated protein 135; SRF-Phox1-interacting protein; SPIN; Williams-Beuren syndrome chromosomal region	WB, IHC-F, IHC-P, ICC/IF	Human
	General Transcription Factor II I Antibody (YA3268) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to General Transcription Factor II I.

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SRF Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SRF Human Pre-designed siRNA Set A contains three designed siRNAs for SRF gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Srf Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Srf Mouse Pre-designed siRNA Set A contains three designed siRNAs for Srf gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Srf Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Srf Rat Pre-designed siRNA Set A contains three designed siRNAs for Srf gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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