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Results for "

TCL 1

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

2

Peptides

1

Natural
Products

1

Recombinant Proteins

2

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-18676B
    ILK-IN-2

    OSU-T315 analog

    		 Integrin Autophagy Apoptosis Caspase PDHK Cancer
    ILK-IN-2 (OSU-T315 analog) is an oral PDK2 inhibitor and also an ILK inhibitor, with an IC50 of 0.6 μM. ILK-IN-2 induces cell autophagy and apoptosis, showing anti-tumor activity. ILK-IN-2 directly abolishes AKT activation by preventing AKT from translocating to lipid rafts, triggering Caspase-dependent apoptosis in chronic lymphocytic leukemia (CLL) and extending the lifespan in TCL1 mouse models .
    ILK-IN-2
  • HY-159808
    TCL1

    		Proteasome Cancer
    TCL1 is a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit in the 19S regulatory particle (19S RP) of the proteasome with an IC50 value of approximately 26 μM. TCL1 interferes with the recognition and transport of ubiquitinated proteins by Rpn-13, inhibits the degradation of proteins by the proteasome, and thus affects the balance of intracellular protein metabolism. TCL1 is promising for research of hematological malignancies .
    TCL1
  • HY-P10105
    TCL1(10-24)

    		Akt Apoptosis Cancer
    TCL1(10-24) is a encompassing the betaA strand of human TCL1. TCL1(10-24) is a Akt inhibitor. TCL1(10-24) interacts with the Akt PH domain prevented phosphoinositide binding and hence inhibits membrane translocation and activation of Akt. TCL1(10-24) inhibits cellular proliferation and anti-apoptosis. TCL1(10-24) has tumor growth in vivo .
    TCL1(10-24)
  • HY-P10049
    TAT-TCL1-Akt-in

    		Akt Cancer
    TAT-TCL1-Akt-in is an Akt inhibitor .
    TAT-TCL1-Akt-in
  • HY-RS14316
    TCL1A Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    TCL1A Human Pre-designed siRNA Set A contains three designed siRNAs for TCL1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TCL1A Human Pre-designed siRNA Set A
    TCL1A Human Pre-designed siRNA Set A
  • HY-RS14317
    TCL1B Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    TCL1B Human Pre-designed siRNA Set A contains three designed siRNAs for TCL1B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TCL1B Human Pre-designed siRNA Set A
    TCL1B Human Pre-designed siRNA Set A
  • HY-RS25978
    Tcl1a Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Tcl1a Rat Pre-designed siRNA Set A contains three designed siRNAs for Tcl1a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Tcl1a Rat Pre-designed siRNA Set A
    Tcl1a Rat Pre-designed siRNA Set A
  • HY-N8177
    Bletilloside A

    		NO Synthase Inflammation/Immunology Cancer
    Bletilloside A is a glycoside. Bletilloside A can be isolated from the tubers of Bletilla striata. Bletilloside A inhibits the expression of the TCL1A protein. When evaluated for its inhibitory activity against LPS-induced NO, Bletilloside A shows an IC50 of >70 μM. Bletilloside A exhibits anticancer activity against acute myeloid leukemia. Bletilloside A can be used in studies related to acute myeloid leukemia .
    Bletilloside A

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