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Cat. No.: HY-187440

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TCL1-PEG4-C2-NH2

TCL1-PEG4-C2-NH2 (Compound 3) is a conjugate of a Rpn13 ligand and a linker, which can be used to synthesize PROTACs such as Truly-4 (HY-187439).

For research use only. We do not sell to patients.

CAS No.: 3119089-68-5
Formula: C₂₉H₃₆BrClN₆O₅S
Molecular Weight:696.06

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TCL1-PEG4-C2-NH2 Chemical Structure

CAS No.: 3119089-68-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

TCL1-PEG4-C2-NH2 (Compound 3) is a conjugate of a Rpn13 ligand and a linker, which can be used to synthesize PROTACs such as Truly-4 (HY-187439)^[1].

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3119089-68-5
Molecular Weight 696.06
Formula C₂₉H₃₆BrClN₆O₅S
SMILES

O=C(NCCOCCOCCOCCOCCN)CC1SC2=NN=C(N2N=C1C3=CC=C(C=C3)Cl)CC4=CC=C(C=C4)Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Loy CA, et al. Two Mechanisms One Molecule: Developing a 'Truly' Bifunctional Degrader Targeting Rpn13 and CRBN. Journal of the American Chemical Society. 2026 Jul 29;148(29):30850-30860.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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