TCL1(10-24)
TCL1(10-24) is a encompassing the betaA strand of human TCL1. TCL1(10-24) is a Akt inhibitor. TCL1(10-24) interacts with the Akt PH domain prevented phosphoinositide binding and hence inhibits membrane translocation and activation of Akt. TCL1(10-24) inhibits cellular proliferation and anti-apoptosis. TCL1(10-24) has tumor growth in vivo.
For research use only. We do not sell to patients.
- CAS No.: 835655-37-3
- Formula: C88H123N23O23
- Molecular Weight:1871.06
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| 184B5 | GI50 |
12.22 μM
Compound: 6, TCL1 10-24
|
Cytotoxicity against human 184B5 cells by SRB assay
Cytotoxicity against human 184B5 cells by SRB assay
|
[PMID: 18691894] |
| 184B5 | GI50 |
7.93 μM
Compound: 6, TCL1 10-24
|
Cytotoxicity against human 184B5 cells at 20 uM chloroquine by SRB assay
Cytotoxicity against human 184B5 cells at 20 uM chloroquine by SRB assay
|
[PMID: 18691894] |
| 184B5 | GI50 |
9.54 μM
Compound: 6, TCL1 10-24
|
Cytotoxicity against human 184B5 cells at 10 uM chloroquine by SRB assay
Cytotoxicity against human 184B5 cells at 10 uM chloroquine by SRB assay
|
[PMID: 18691894] |
| MCF7 | GI50 |
16.52 μM
Compound: 6, TCL1 10-24
|
Cytotoxicity against human MCF7 cells in presence of 10 uM chloroquine by SRB assay
Cytotoxicity against human MCF7 cells in presence of 10 uM chloroquine by SRB assay
|
[PMID: 18691894] |
| MCF7 | GI50 |
23.45 μM
Compound: 6, TCL1 10-24
|
Cytotoxicity against human MCF7 cells by SRB assay
Cytotoxicity against human MCF7 cells by SRB assay
|
[PMID: 18691894] |
| MCF7 | GI50 |
8.52 μM
Compound: 6, TCL1 10-24
|
Cytotoxicity against human MCF7 cells in presence of 20 uM chloroquine by SRB assay
Cytotoxicity against human MCF7 cells in presence of 20 uM chloroquine by SRB assay
|
[PMID: 18691894] |
| MDA-MB-231 | GI50 |
14.37 μM
Compound: 6, TCL1 10-24
|
Cytotoxicity against human MDA-MB-231 cells in presence of 10 uM chloroquine by SRB assay
Cytotoxicity against human MDA-MB-231 cells in presence of 10 uM chloroquine by SRB assay
|
[PMID: 18691894] |
| MDA-MB-231 | GI50 |
17.8 μM
Compound: 6, TCL1 10-24
|
Cytotoxicity against human MDA-MB-231 cells by SRB assay
Cytotoxicity against human MDA-MB-231 cells by SRB assay
|
[PMID: 18691894] |
| MDA-MB-231 | GI50 |
8.21 μM
Compound: 6, TCL1 10-24
|
Cytotoxicity against human MDA-MB-231 cells in presence of 20 uM chloroquine by SRB assay
Cytotoxicity against human MDA-MB-231 cells in presence of 20 uM chloroquine by SRB assay
|
[PMID: 18691894] |
| MDA-MB-468 | GI50 |
15.02 μM
Compound: 6, TCL1 10-24
|
Cytotoxicity against human MDA-MB-468 cells in presence of 10 uM chloroquine by SRB assay
Cytotoxicity against human MDA-MB-468 cells in presence of 10 uM chloroquine by SRB assay
|
[PMID: 18691894] |
| MDA-MB-468 | GI50 |
19.95 μM
Compound: 6, TCL1 10-24
|
Cytotoxicity against human MDA-MB-468 cells by SRB assay
Cytotoxicity against human MDA-MB-468 cells by SRB assay
|
[PMID: 18691894] |
| MDA-MB-468 | GI50 |
9.98 μM
Compound: 6, TCL1 10-24
|
Cytotoxicity against human MDA-MB-468 cells in presence of 20 uM chloroquine by SRB assay
Cytotoxicity against human MDA-MB-468 cells in presence of 20 uM chloroquine by SRB assay
|
[PMID: 18691894] |
Chemical Information
-
CAS No. 835655-37-3
-
Molecular Weight 1871.06
-
Formula C88H123N23O23
-
Sequence
Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe
-
Sequence Shortening
AVTDHPDRLWAWEKF
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)