56 Results for "

TIGIT

" in MedChemExpress (MCE) Product Catalog:
Products (56)

56 Results for "TIGIT" in MCE Product Catalog:

44
44 Cited Publications
Cat. No.: HY-A0070A
CAS No.: 6893-02-3
Synonyms: Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3
Liothyronine is an active form of thyroid hormone. Liothyronine binds to thyroid hormone receptors TRα and TRβ with Kis of 2.33 and 2.29 nM for hTRα and hTRβ, respectively. Liothyronine also binds to PVR and blocks the interaction of TIGIT/PVR .
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Cat. No.: HY-P9986
CAS No.: 1918185-84-8
Synonyms: MTIG-7192A; RG-6058

Target:  

CD28

Research Areas:  

Cancer

Tiragolumab is an immune checkpoint inhibitor binding to the T-cell immunoglobulin and ITIM domain (TIGIT). Tiragolumab in combination with Atezolizumab (HY-P9904) and Bevacizumab (HY-P9906) has benefit in unresectable hepatocellular carcinoma. Tiragolumab can be used to study non-small cell lung cancer (NSCLC) and melanoma .
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Cat. No.: HY-P990155
Anti-Mouse TIGIT Antibody (1G9) is a mouse-derived agonistic TIGIT IgG1 κ type antibody. Anti-Mouse TIGIT Antibody (1G9) blocks CD155 binding to TIGIT. Anti-Mouse TIGIT Antibody (1G9) shows potent anti-infection and anti-immune effects in septic and experimental autoimmune encephalomyelitis .
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Cat. No.: HY-P99202
CAS No.: 2231305-30-7

Research Areas:  

Cancer

Vibostolimab is an anti-TIGIT (T cell immunoglobulin and ITIM domain) monoclonal antibody. Vibostolimab shows antitumor activity, and can be used in non-small cell lung cancer (NSCLC) and melanoma research .
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Cat. No.: HY-P99858
CAS No.: 2368219-35-4
Synonyms: AB154

Research Areas:  

Cancer

Domvanalimab (AB154) is an anti-TIGIT humanized monoclonal antibody. Domvanalimab binds human TIGIT9 and blocks the TIGIT-CD155 interaction. Domvanalimab can be used for studies of non-small cell lung cancer and esophageal cancer .
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Cat. No.: HY-P99763
CAS No.: 2342597-93-5
Synonyms: BGB-A1217

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

Ociperlimab is a humanized IgG1 anti-TIGIT antibody. Ociperlimab binds to the extracellular domain of human TIGIT with high affinity (KD = 0.135 nM). Ociperlimab blocks the interaction between TIGIT and its ligands PVR or PVR-L2. Ociperlimab can be used in research of cancer .
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Cat. No.: HY-P990704
CAS No.: 2640305-01-5
Synonyms: AZD-2936

Research Areas:  

Cancer

Rilvegostomig (AZD-2936) is a bispecific humanized IgG1 antibody targeting PD-1 and TIGIT. Rilvegostomig induces tumor growth inhibition and modulates the tumor immune microenvironment. Rilvegostomig exhibits anti-tumor activity in metastatic non-small cell lung cancer (without prior immune checkpoint inhibitor treatment). Rilvegostomig can be used in research related to metastatic non-small cell lung cancer and endometrial cancer .
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Cat. No.: HY-P990032
CAS No.: 2574438-65-4
Synonyms: EOS-448; EOS884448; GSK4428859A
Belrestotug (EOS-448) is an antagonistic anti-TIGIT (VSIG9, VSTM3) human immunoglobulin G1 kappa (hIgG1 kappa) antibody. Belrestotug shows antineoplastic activity. Belrestotug can be used for cancer and immunological research such as colon cancer .
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Cat. No.: HY-P990079
CAS No.: 2725062-35-9
Synonyms: BMS-986207; ONO-4686

Target:  

CD28

Research Areas:  

Inflammation/Immunology

Renvistobart is an immunoglobulin G1-κ, anti-[Homo sapiens TIGIT (T cell immunoreceptor with Ig domain and ITIM, VSIG9, VSTM3)] Homo sapiens monoclonal antibody .
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Cat. No.: HY-P99949
CAS No.: 2044984-83-8
Synonyms: OMP-313M32

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

Etigilimab (OMP-313M32), a humanized IgG1 monoclonal antibody, blocks TIGIT interaction with PVR (CD155; poliovirus receptor) and inhibits downstream signalling with target cell killing .
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Cat. No.: HY-P991389

Research Areas:  

Cancer

BAT-6005 is a human monoclonal antibody (mAb) targeting TIGIT. BAT-6005 can be used in Tumor Immunity research .
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Cat. No.: HY-P991111

Research Areas:  

Inflammation/Immunology

Anti-Mouse TIGIT Antibody (10A7) is a mouse IgG2 monoclonal antibody that targets TIGIT. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978).
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Cat. No.: HY-P991391

Research Areas:  

Cancer

COM902 is a human IgG4 monoclonal antibody (mAb) targeting TIGIT. COM902 enhances anti-tumor immune responses. COM902 can be used in Multiple myeloma, Solid tumours and Colorectal cancer research. Recommended isotype control: IgG4-lambda .
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Cat. No.: HY-P990030
CAS No.: 2581724-89-0
Synonyms: AB-308
Ralzapastotug (AB-308) is an anti-TIGIT (T cell immunoreceptor with Ig and ITIM domains) IgG1 monoclonal antibody .
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Cat. No.: HY-P990031
CAS No.: 2649362-29-6
Synonyms: M-6223
Dargistotug (M-6223) is a fully human IgG1 monoclonal antibody targeting TIGIT (T cell immune receptor with Ig domain and ITIM). TIGIT is an inhibitory immune checkpoint that promotes NK cell depletion and reduces the secretion of cytokines by binding to CD155 and other antibodies. It can also directly or indirectly inhibit effector T cells and upregulate Tregs cells, thereby exerting immunosuppression. Function .
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Cat. No.: HY-P991475

Research Areas:  

Cancer

MG-1131 is a human monoclonal antibody (mAb) targeting TIGIT. MG-1131 activates NF-κB signaling in T cells and enhances NK-mediated tumor killing activity in a PVR-dependent manner. MG-1131 blocks TIGIT to increase IFN-γ secretion. MG-1131 can be used in anti-tumor immunity research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-P991393

Research Areas:  

Cancer

ASP8374 is a human IgG4 monoclonal antibody (mAb) targeting TIGIT. ASP8374 increases IL-2 production in Jurkat cells and IFN-γ and TNF-α production in human PBMCs. ASP8374 can be used in advanced solid tumors research. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003) .
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Cat. No.: HY-A0070AS5
Synonyms: Triiodothyronine-d4; 3,3',5-Triiodo-L-thyronine-d4; T3-d4
Liothyronine-d4 (Triiodothyronine-d4) is the deuterium labeled Liothyronine (HY-A0070A). Liothyronine is an active form of thyroid hormone. Liothyronine binds to thyroid hormone receptors TRα and TRβ with vs of 2.33 and 2.29 nM for hTRα and hTRβ, respectively. Liothyronine also binds to PVR and blocks the interaction of TIGIT/PVR .
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Cat. No.: HY-P991620

Research Areas:  

Cancer

JS006 is a humanized IgG4κ monoclonal antibody inhibitor targeting TIGIT/CD155. JS006 can be used to study advanced and/or metastatic cancers with resistance to PD-1/PD-L1 inhibitor such as non-small cell lung cancer (NSCLC), advanced lymphoma and advanced/metastatic triple negative breast cancer (TNBC) .
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Cat. No.: HY-RS14524
Research Areas:  

Others

TIGIT Human Pre-designed siRNA Set A contains three designed siRNAs for TIGIT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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