18 Results for "

TSLP Antibody

" in MedChemExpress (MCE) Product Catalog:
Products (18)

18 Results for "TSLP Antibody" in MCE Product Catalog:

Cat. No.: HY-P811326
Synonyms: Thymic stromal lymphopoietin, Thymic stroma-derived lymphopoietin, TSLP

Host:  

Rabbit

Application:  

WB, ICC/IF

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P99366A
CAS No.: 1572943-04-4
Synonyms: AMG 157 (anti-TSLP); MEDI 19929 (anti-TSLP); Tezepelumab-ekko (anti-TSLP)

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Tezepelumab (anti-TSLP) is human monoclonal antibody (IgG2λ) that binds specifically to TSLP, blocking it from interacting with its heterodimeric receptor. Tezepelumab can be used for the research of severe, uncontrolled asthma .
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Cat. No.: HY-P990774
CAS No.: 2768386-15-6
Synonyms: ASP-7266; TRAB-1; UPB-101

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Verekitug (ASP-7266; TRAB-1; UPB-101) is a human monoclonal antibody targeting the thymic stromal lymphopoietin receptor (TSLPR), with a mean half-life of approximately 20 days. At doses of Verekitug ≥100 mg, complete and sustained TSLPR-specific occupancy is achieved, and the antibody does not bind to IL-7Rα. By inhibiting TSLP-driven inflammatory responses, Verekitug blocks TSLP-induced cell proliferation and TARC expression, while reducing fractional exhaled NO levels, blood eosinophil counts, and levels of IL-5 and IgE. Verekitug significantly improves scores for nasal polyps, nasal congestion and olfactory dysfunction, with favorable safety and good tolerability; potential adverse reactions include headache, upper respiratory tract infection, sinusitis and nasopharyngitis. Verekitug is used in relevant studies on asthma, chronic rhinosinusitis with nasal polyps and chronic obstructive pulmonary disease .
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Cat. No.: HY-P991471

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

GB-0895 is a human monoclonal antibody (mAb) targeting TSLP. GB-0895 can be used in Asthma research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-P991162
CAS No.: 2981469-90-1
Synonyms: PF-07275315
Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Tilrekimig (PF-07275315) is a monoclonal antibody targeting human interleukin-4 (IL-4), interleukin-13 (IL-13) and thymic stromal lymphopoietin (TSLP). Tilrekimig can be used in the research of allergic and inflammatory diseases, such as asthma and atopic dermatitis .
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Cat. No.: HY-P990906
CAS No.: 2762183-23-1
Synonyms: BSI-045B; TQC2731

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Bosakitug (BSI-045B) is an TSLP-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001). Bosakitug can be used in the research of inflammatory diseases such as moderate to severe atopic dermatitis .
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Cat. No.: HY-P990933
CAS No.: 2803351-66-6
Synonyms: CM-326

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Ocankitug (CM-326) is a humanized IgG1κ antibody targeting thymic stromal lymphopoietin (TSLP). It can be used for research on type 2 inflammatory respiratory diseases, including moderate to severe asthma, chronic sinusitis with nasal polyps, etc.
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Cat. No.: HY-P990023
CAS No.: 2622254-57-1
Synonyms: ADX-914

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Bempikibart (ADX-914) is a fully human anti-IL-7Rα antibody that re-regulates adaptive immune function by blocking signaling mediated by both IL-7 and thymic stromal lymphopoietin (TSLP). Bempikibart can be used for the study of atopic dermatitis and alopecia areata .
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Cat. No.: HY-P99872
CAS No.: 2415207-91-7
Synonyms: CSJ-117; NVP-CSJ117

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Ecleralimab (CSJ-117; NVP-CSJ117) is a Fab-IgG1-λ2 antibody targeting the thymic stromal lymphopoietin (TSLP). Ecleralimab significantly attenuates allergen-induced airway responses and inflammation. Ecleralimab can be used for the study of inhaled asthma .
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Cat. No.: HY-P990150

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Anti-Mouse TSLP Antibody (28F12) is an anti-mouse TSLP IgG2a monoclonal antibody. Anti-Mouse TSLP Antibody (28F12) weakens skin inflammation and allergic reactions by reducing Treg cells and lymph node cells. Anti-Mouse TSLP Antibody (28F12) can be used for research on allergic conditions .
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Cat. No.: HY-P991717
CAS No.: 2928519-36-0
Synonyms: AZD-8630

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Sunakiment (AZD-8630) is a humanized IgG1λ monoclonal antibody inhibitor targeting thymic stromal lymphopoietin (TSLP), which enables direct airway delivery via a dry powder inhaler formulation. Sunakiment binds to TSLP and blocks its pro-inflammatory signal transduction. It is applicable to research on refractory asthma, asthma, and moderate-to-severe asthma .
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Cat. No.: HY-P990535

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Anti-TSLP Antibody is a human-derived antibody expressed in CHO cells, targeting TSLP. The Anti-TSLP Antibody contains the huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-TSLP Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
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Cat. No.: HY-P991720
CAS No.: 2985643-31-8

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Tepilukimig is a bivalent humanized IgG1κ monoclonal antibody inhibitor targeting TSLP-IL7Rα and TSLP-CRLF2. Tepilukimig inhibits the binding of TSLP to its receptors (IL7Rα and CRLF2) on the cell surface, thereby completely interrupting the inflammatory signaling pathway driven by TSLP. Tepilukimig can be used for allergic and inflammatory diseases like atopic dermatitis and asthma research .
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Cat. No.: HY-P991684
CAS No.: 3036134-89-8

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Felcorekibart is a humanized IgG1κ antibody targeting TSLP. The corresponding isotype control is: Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-P992452

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

RO-5469754 is a humanized monoclonal antibody that specifically binds to human thymic stromal lymphopoietin (TSLP). RO-5469754 blocks the binding of hTSLP to its receptor complex, thereby neutralizing TSLP-mediated biological activities, and does not cross-react with TSLP from cynomolgus monkeys or mice. RO-5469754 can be further used to generate the bispecific antibody TAVO101 × IL4R-dupi .
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Cat. No.: HY-P992447

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

QX008N is a humanized IgG1 monoclonal antibody and also a TSLP inhibitor with a KD value of 0.0175 nM. QX008N blocks TSLP-induced signaling pathways by inhibiting the interaction of TSLP-TSLPR-IL-7Rα. QX008N reduces eosinophil and IgE levels, improves pulmonary function, blocks TSLP-induced inflammation, and enhances the inhibitory effect on inflammatory mediators when administered in combination with anti-IL-4R antibodies. QX008N is applicable to relevant research on asthma .
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Cat. No.: HY-P992359
Synonyms: SHR-1905

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

GSK5784283 (SHR-1905) is a bivalent antibody against TSLP, which is applicable to research related to asthma. GSK5784283 has two Fab arms and is a humanized IgG1κ monoclonal antibody. GSK5784283 effectively reduces the levels of eosinophils, FeNO, TARC and eotaxin-3. GSK5784283 regulates FEV1 (forced expiratory volume in one second) .
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Cat. No.: HY-P992474
TAVO101 is a humanized anti-TSLP antibody with an EC50 of 0.19 nM against hTSLP. TAVO101 inhibits STAT5 activation and CCL17 release. TAVO101 carries Fc region mutations that enhance its binding to FcRn while reducing its binding to FcγRI, FcγRIIIA and C1q, thereby attenuating effector functions. TAVO101 reduces the levels of inflammatory markers, cell infiltration and histopathological damage in preclinical models of asthma, psoriasis and atopic dermatitis. TAVO101 can be used for research related to asthma, psoriasis and atopic dermatitis .
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