Anti-Mouse TSLP Antibody (28F12)
Based on 1 Customer Validation
Anti-Mouse TSLP Antibody (28F12) is an anti-mouse TSLP IgG2a monoclonal antibody. Anti-Mouse TSLP Antibody (28F12) weakens skin inflammation and allergic reactions by reducing Treg cells and lymph node cells. Anti-Mouse TSLP Antibody (28F12) can be used for research on allergic conditions.
For research use only. We do not sell to patients.
- Purity: 98.395%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Rat IgG2a kappa
Mouse
TSLP
Anti-Mouse TSLP Antibody (28F12) (1 μg/mL) inhibits TSLP dependent proliferation in NAG8/7 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Anti-Mouse TSLP Antibody (28F12) (200 μg, i.p., twice a week, for 4 weeks) significantly inhibits the expansion of Treg cells in C57BL/6 mice with an altered Schaedler flora (ASF) colonization[2].
Anti-Mouse TSLP Antibody (28F12) (250 μg, i.v., single dose, on day 0) significantly inhibits Th2 differentiation but does not affect the migration and maturation of eosinophils or dendritic cells in BALB/c or C57BL/6 mice induced by Papain (HY-P1645)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Triclosan induced female BALB/c mice (6-8 weeks)[1]
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Dosage:200-400 μg
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Administration:Intraperitoneal injection (i.p.), once every 3 days, for 7 days
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Result:Reduced the level of TSLP and IL-1β.
Reduced the numbers of B cells and dendritic cells (DCs).
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Animal Model:C57BL/6 mice with an ASF colonization[2]
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Dosage:200 μg
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Administration:Intraperitoneal injection (i.p.), twice a week, for 4 weeks
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Result:Reduced the number of Treg cells.
Exacerbated Th17 and IFNγ responses.
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Animal Model:Papain (50 μg) induced BALB/c or C57BL/6 mice[3]
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Dosage:250 μg
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Administration:Intravenous injection (i.v.), single dose on day 0
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Result:Significantly inhibited Th2 differentiation.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
in vivo TSLP neutralization; in vitro TSLP neutralization
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Immobilized TSLP Protein, Mouse (HEK293, Fc, HY-P70626) can bind Anti-Mouse TSLP Antibody (28F12). The EC50 for this effect is 8.511 ng/mL.
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse TSLP Antibody (28F12)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Marshall NB, et al. Triclosan Induces Thymic Stromal Lymphopoietin in Skin Promoting Th2 Allergic Responses. Toxicol Sci. 2015 Sep;147(1):127-39. [Content Brief]
[2]. Mosconi I, et al. Intestinal bacteria induce TSLP to promote mutualistic T-cell responses. Mucosal Immunol. 2013 Nov;6(6):1157-67. [Content Brief]
[3]. Sokol CL, et al. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol. 2008 Mar;9(3):310-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse TSLP Antibody (28F12) Related Classifications
HY-P990150 Related Classifications
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