Tslp - thymic stromal lymphopoietin Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 53603

Summary

Enables cytokine activity. Predicted to be involved in several processes, including defense response to Other organism; positive regulation of cytokine production; and positive regulation of signal transduction. Predicted to be located in extracellular region. Is expressed in ductus deferens; epididymis; ileum; and testis. Used to study atopic dermatitis; autoimmune hemolytic anemia; cryoglobulinemia; and membranoproliferative glomerulonephritis. Orthologous to human TSLP (thymic stromal lymphopoietin). [provided by Alliance of Genome Resources, Apr 2022]

Tslp Products (1)

mRNA Protein Name
NM_021367.2 NP_067342.1 thymic stromal lymphopoietin precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
10974033 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
24632570 MGI
Cellular Component GO Annotation Evidence References Source
is active in extracellular space IDA
IDA: Inferred from direct assay
28811323 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thymic stromal lymphopoietin

  • thymic stroma-derived lymphopoietin

Tslp Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Tslp Q9JIE6 Crlf2 Mus musculus Q8CII9
GMS
24632570
Intra
Tslp Q9JIE6 Crlf2 Mus musculus Q8CII9
Light Scattering
24632570
Intra
Tslp Q9JIE6 Crlf2 Mus musculus Q8CII9
ITC
24632570
Intra
Tslp Q9JIE6 Crlf2 Mus musculus Q8CII9
SPR
24632570
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Tslp Proteins

Cat. No. Product Name Accession Purity
HY-P70626 TSLP Protein, Mouse (HEK293, Fc) Q9JIE6 (Y20-E140) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78790 TSLP Protein, Mouse (Biotinylated, HEK293, His-Avi) Q9JIE6 (Y20-E140) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-W341962 Halometasone Inhibitor 98.47% Phase 4
HY-150207 RBN-3143 Inhibitor 99.29% Phase 1
Inhibitory Antibodies (7)
Cat. No. Product Name Effect
Purity Phase
HY-P99366A Tezepelumab (anti-TSLP) ≥99.0% Phase 4
HY-P990748 Lunsekimig Inhibitor 99.00% Phase 3
HY-P990906 Bosakitug 99.00% Phase 3
HY-P990933 Ocankitug ≥99.0% Phase 3
HY-P991471 GB-0895 Inhibitor 96.67% Phase 3
HY-P990023 Bempikibart Antagonist 98.00% Phase 2
HY-P99872 Ecleralimab Inhibitor 97.35% Phase 2

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-163731 EGR-1-IN-1 Inhibitor 99.07% Unkown
HY-170415 EGR-1-IN-3 Inhibitor 99.13% Unkown
HY-207120 TSLP-IN-1 Inhibitor 99.67% Unkown
HY-206870 BP79 Inhibitor / Unkown
HY-158990 GE1111 95.73% Unkown
HY-181006 TSLP modulator-1 Inhibitor 99.61% Unkown
HY-181576 ROCK2-IN-14 Inhibitor / Unkown
HY-182362 TK-285 / Unkown
HY-404647 FK3453 Inhibitor 99.98% Unkown
HY-RS15153 TSLP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N3989 Haplopine 99.49% Unkown
HY-RS16628 Tslp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23063 Tslp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990774 Verekitug Inhibitor 97.00% Unkown
HY-P990150 Anti-Mouse TSLP Antibody (28F12) Inhibitor 98.395% Unkown
HY-P991162 Tilrekimig Inhibitor 97.00% Unkown
HY-P991684 Felcorekibart Inhibitor 99.637% Unkown
HY-P991720 Tepilukimig Inhibitor 95.57% Unkown
HY-P992474 TAVO101 96.62% Unkown
HY-P990535 Anti-TSLP Antibody Inhibitor / Unkown
HY-P991717 Sunakiment Inhibitor / Unkown
HY-P992378 HZ-1127 Inhibitor / Unkown
HY-P992447 QX008N Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tslp NCBI NCBI:85480