Ocankitug
Based on 1 Customer Validation
Ocankitug (CM-326) is a humanized IgG1κ antibody targeting thymic stromal lymphopoietin (TSLP). It can be used for research on type 2 inflammatory respiratory diseases, including moderate to severe asthma, chronic sinusitis with nasal polyps, etc.
For research use only. We do not sell to patients.
- Purity: ≥99.0%
- CAS No.: 2803351-66-6
- Molecular Weight:145.32 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
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Help & FAQs
Biological Activity
Human IgG1 kappa
Human
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IL7R |
Ocankitug binds to TSLP with high affinity, blocking its interaction with the receptor (TSLPR/IL-7Rα), thereby inhibiting the activation of downstream dendritic cells, Th2 cells, and eosinophils, and interfering with the type 2 inflammatory pathway at its source.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Q969D9-1
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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IgG1-kappa
ELISA, FACS, Functional assay
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Immobilized TSLP Protein, Human (HEK293, His, HY-P70818) can bind Ocankitug. The EC50 for this effect is 2.541 ng/mL.
Chemical Information
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CAS No. 2803351-66-6
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Appearance Liquid
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Molecular Weight 145.32 kDa
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Color Colorless to light yellow
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SMILES
[Ocankitug]
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Synonyms
CM-326
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (230 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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