Ocankitug (Synonyms: CM-326)

Cat. No.: HY-P990933 Purity: ≥99.0%: Data Sheet
COA

SDS

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Technical Support

Ocankitug (CM-326) is a humanized IgG1κ antibody targeting thymic stromal lymphopoietin (TSLP). It can be used for research on type 2 inflammatory respiratory diseases, including moderate to severe asthma, chronic sinusitis with nasal polyps, etc.

For research use only. We do not sell to patients.

CAS No. : 2803351-66-6

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Biological Activity
Purity & Documentation
Customer Review

Description

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

IL7R

In Vitro

Ocankitug binds to TSLP with high affinity, blocking its interaction with the receptor (TSLPR/IL-7Rα), thereby inhibiting the activation of downstream dendritic cells, Th2 cells, and eosinophils, and interfering with the type 2 inflammatory pathway at its source.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Gene ID

85480 [NCBI]

Accession

Q969D9-1

Application

ELISA, FACS, Functional assay

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

145.32 kDa

CAS No.

2803351-66-6

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Ocankitug]

Shipping

Shipping with dry ice.

Formulation

Please refer to the lot-specific COA for specific buffer information.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Format

IgG1-kappa

Biological Activity

Immobilized TSLP Protein, Human (HEK293, His, HY-P70818) can bind Ocankitug. The EC₅₀ for this effect is 2.541 ng/mL.

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (230 KB) SDS (251 KB)

COA (232 KB) SDS-PAGE (66 KB) SEC-HPLC (122 KB)

Inhibitory Antibodies User Guide (603 KB)

Ocankitug Related Classifications

Inflammation/Immunology

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ocankitug2803351-66-6CM-326CM326CM 326Interleukin RelatedILInhibitorinhibitorinhibit

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