Bosakitug
Based on 1 Customer Validation
Bosakitug (BSI-045B) is an TSLP-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001). Bosakitug can be used in the research of inflammatory diseases such as moderate to severe atopic dermatitis.
For research use only. We do not sell to patients.
- Purity: 99.00%
- CAS No.: 2762183-23-1
- Molecular Weight:145.507 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG1 kappa
Human
TSLP
TSLP is a key regulator of type 2 (Th2) immune responses at the barrier surfaces of the skin, respiratory tract, and gastrointestinal tract. The expression level of TSLP is significantly elevated in models of atopic diseases such as atopic dermatitis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Q969D9-1
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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IgG1-kappa
ELISA, FACS, Functional assay
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Loaded Bosakitug on AHC2 biosensor, can bind TSLP Protein, Human (HEK293, His, HY-P70818) with an affinity constant of 4.639E-10 M as determined in BLI assay.
Chemical Information
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CAS No. 2762183-23-1
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Appearance Liquid
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Molecular Weight 145.507 kDa
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Color Colorless to light yellow
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SMILES
[Bosakitug]
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Synonyms
BSI-045B; TQC2731
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (256 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)