2. Epigenetics
  3. Epigenetic Reader Domain
  4. TK-285

TK-285 is a potent TSLP inhibitor that suppresses the production of TSLP and inhibits the expression of interleukin-33 mRNA. TK-285 exhibits a selective binding preference for the BD1 domains of BRD2, BRD3, BRD4 and BRDT. TK-285 can be used in research related to atopic dermatitis.

For research use only. We do not sell to patients.

TK-285

TK-285 Chemical Structure

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TK-285 Related Antibodies

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Description

TK-285 is a potent TSLP inhibitor that suppresses the production of TSLP and inhibits the expression of interleukin-33 mRNA. TK-285 exhibits a selective binding preference for the BD1 domains of BRD2, BRD3, BRD4 and BRDT. TK-285 can be used in research related to atopic dermatitis[1].

In Vitro

TK-285 (0.1-10 μM; 24 h) dose-dependently inhibits TSLP production in mouse keratinocyte KCMH-1 cells after 24 h treatment, achieving significant inhibition at concentrations as low as 0.3 μM[1].
TK-285 binds strongly to the BD1 domain of BRD4 with a Kd of 190 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TK-285 Related Antibodies
Molecular Weight

474.55

Formula

C28H30N2O5
SMILES

CC(NCCC1=C(C(/C=C/C2=CC=CC=C2OCC3=CN=CC=C3)=O)C=C(OCC)C(OC)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TK-285 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TK-285TK285TK 285Epigenetic Reader Domainubiquitinationinterleukin-33BD1 domainscereblon E3 ubiquitin ligaseBRD2BRD3BRD4thymic stromal lymphopoietinmouse keratinocyte KCMH-1 cellsproteasomal degradationInhibitorinhibitorinhibit

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