TK-285
TK-285 is a potent TSLP inhibitor that suppresses the production of TSLP and inhibits the expression of interleukin-33 mRNA. TK-285 exhibits a selective binding preference for the BD1 domains of BRD2, BRD3, BRD4 and BRDT. TK-285 can be used in research related to atopic dermatitis.
For research use only. We do not sell to patients.
- Formula: C28H30N2O5
- Molecular Weight:474.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
TK-285 (0.1-10 μM; 24 h) dose-dependently inhibits TSLP production in mouse keratinocyte KCMH-1 cells after 24 h treatment, achieving significant inhibition at concentrations as low as 0.3 μM[1].
TK-285 binds strongly to the BD1 domain of BRD4 with a Kd of 190 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 474.55
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Formula C28H30N2O5
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SMILES
CC(NCCC1=C(C(/C=C/C2=CC=CC=C2OCC3=CN=CC=C3)=O)C=C(OCC)C(OC)=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TK-285 Related Classifications
HY-182362 Related Classifications
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