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Triflate

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By Targets:	17β-HSD (1) Bacterial (1) Biochemical Assay Reagents (5) Endogenous Metabolite (1) Fluorescent Dye (1) G-quadruplex (1) Herbicide (1) Isotope-Labeled Compounds (2) Sirtuin (1)
By Research Areas:	Cancer (4) Infection (1) Metabolic Disease (2) Neurological Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15594A

Phen-DC3 Trifluoromethanesulfonate 5+ Cited Publications Phen-DC3 Triflate	G-quadruplex	Cancer
Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC₅₀s of 65±6 and 50±10 nM, respectively.

HY-19997

Mannose triflate TATM	Biochemical Assay Reagents	Cancer
Mannose triflate is a glucose analog. Mannose triflate is a precursor for 18F-FDG synthesis for PET applications. Mannose triflate binds to 18F via SN2 nucleophilic substitution reaction. Mannose triflate can be used for an imaging technique in detection of cancer .

HY-21170B

Trifluoromethanesulfonate lithium Triflate lithium; Trifluoromethylsulfonate lithium; Trifluoromethanesulphonic acid lithium	Biochemical Assay Reagents Herbicide	Others
Trifluoromethanesulfonate (Triflate;Trifluoromethylsulfonate) lithium is a stable lithium salt and dopant with four resonance states, which is commonly used as an electrolyte component in polymer light-emitting electrochemical cells and primary lithium batteries. Trifluoromethanesulfonate lithiumalso acts as a catalyst for the preparation of the herbicide Imazapyr. In MEH-PPV-based light-emitting electrochemical cells, Trifluoromethanesulfonate lithium promotes electrochemical p-type doping at the anode interface under applied bias, thereby facilitating the formation of p-i-n junctions, exciton generation, and light emission. Trifluoromethanesulfonate lithiumexhibits strong ion pairing in non-aqueous electrolytes, but its electrochemical stability window is narrower than that of lithium bistrifluoromethylsulfonyl imidee .

HY-169331

H2S scavenger 1 triflate	Bacterial	Infection
H2S scavenger 1 triflate is a selective H₂S scavenger and antibacterial adjuvant. H2S scavenger 1 triflate consumes hydrogen sulfide produced by H₂S-producing bacteria via chemical scavenging, and does not act on H₂S synthases. H2S scavenger 1 triflate enhances the clearance of H₂S-producing bacteria mediated by macrophages and polymorphonuclear neutrophils. H2S scavenger 1 triflate inhibits the biofilm formation of H₂S-producing bacteria and eliminates pre-formed biofilms. H2S scavenger 1 triflate can be used for the research of Pseudomonas aeruginosa-infected pneumonia and Pseudomonas aeruginosa-infected skin wounds .

HY-21170E

Zinc trifluoromethanesulfonate Zinc(II) Triflate	Biochemical Assay Reagents	Others
Zinc trifluoromethanesulfonate (Zinc (II) Triflate) is a Zn ²⁺ salt commonly used in potentiometric titration to determine the stability constants of Zn ²⁺-quinoline sulfonamide complexes. Aqueous solutions of Zinc trifluoromethanesulfonate form micellar structures, which result in poor desolvation kinetics of Zn ²⁺ and induce dendrite growth on zinc anodes, failing to support long-term cycling of zinc anodes .

HY-123033D

Nicotinamide riboside triflate	Endogenous Metabolite Sirtuin	Neurological Disease Metabolic Disease Cancer
Nicotinamide riboside triflate, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates SIRT1 and SIRT3. Nicotinamide riboside triflate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside triflate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-W767484

Nicotinamide riboside-d4 triflate Nicotinamide riboside-d₄ Triflate (d3-major)a/b mixture	Isotope-Labeled Compounds	Others
Nicotinamide riboside-d₄ (triflate) (Nicotinamide riboside-d₄ triflate (d3-major)a/b mixture) is deuterium labeled Nicotinamide riboside (triflate) .

HY-117268

1,3,4,6-Tetra-O-acetyl-β-D-mannopyranose	Biochemical Assay Reagents	Others
1,3,4,6-Tetra-O-acetyl-β-D-mannopyranose is a key intermediate in the preparation of the triflate precursor .

HY-142448S

Nicotinic acid riboside methyl ester-d4 triflate	Isotope-Labeled Compounds	Others
Nicotinic acid riboside methyl ester-d4 triflate is the deuterium labeled Nicotinic acid riboside methyl ester triflate .

HY-121564

Radermachol	Fluorescent Dye	Others
Radermachol is a red pigment that can be synthesized in four steps via a key ytterbium triflate-catalyzed furan cyclization and intramolecular nucleophilic acylation reaction .

HY-43322

7-Coumaryl triflate	17β-HSD	Cancer
7-Coumaryl triflate is a type 17β-HSD1 inhibitor of 17β-hydroxysteroid dehydrogenase. Its IC₅₀ is 360 nM and K_i is 173 nM. 7-Coumaryl triflate shows selectivity for 17β-HSD2 and has no detectable affinity for ERα or ERβ. 7-Coumaryl triflate can be used in related research on hormone-dependent breast cancer .

HY-166217

Heptyl methane sulfonate Heptyl mesylate; n-Heptyl methanesulfonate; Heptyl Triflate	Biochemical Assay Reagents	Metabolic Disease
Heptyl methane sulfonate (Heptyl mesylate; n-Heptyl methanesulfonate; Heptyl triflate) is an ester product.

Cat. No.	Product Name	Type

HY-19997

Mannose triflate TATM	Biochemical Assay Reagents
Mannose triflate is a glucose analog. Mannose triflate is a precursor for 18F-FDG synthesis for PET applications. Mannose triflate binds to 18F via SN2 nucleophilic substitution reaction. Mannose triflate can be used for an imaging technique in detection of cancer .

HY-21170B

Trifluoromethanesulfonate lithium Triflate lithium; Trifluoromethylsulfonate lithium; Trifluoromethanesulphonic acid lithium	Biochemical Assay Reagents
Trifluoromethanesulfonate (Triflate;Trifluoromethylsulfonate) lithium is a stable lithium salt and dopant with four resonance states, which is commonly used as an electrolyte component in polymer light-emitting electrochemical cells and primary lithium batteries. Trifluoromethanesulfonate lithiumalso acts as a catalyst for the preparation of the herbicide Imazapyr. In MEH-PPV-based light-emitting electrochemical cells, Trifluoromethanesulfonate lithium promotes electrochemical p-type doping at the anode interface under applied bias, thereby facilitating the formation of p-i-n junctions, exciton generation, and light emission. Trifluoromethanesulfonate lithiumexhibits strong ion pairing in non-aqueous electrolytes, but its electrochemical stability window is narrower than that of lithium bistrifluoromethylsulfonyl imidee .

Trifluoromethanesulfonate lithium

Triflate lithium; Trifluoromethylsulfonate lithium; Trifluoromethanesulphonic acid lithium

Biochemical Assay Reagents

Trifluoromethanesulfonate (Triflate;Trifluoromethylsulfonate) lithium is a stable lithium salt and dopant with four resonance states, which is commonly used as an electrolyte component in polymer light-emitting electrochemical cells and primary lithium batteries. Trifluoromethanesulfonate lithiumalso acts as a catalyst for the preparation of the herbicide Imazapyr. In MEH-PPV-based light-emitting electrochemical cells, Trifluoromethanesulfonate lithium promotes electrochemical p-type doping at the anode interface under applied bias, thereby facilitating the formation of p-i-n junctions, exciton generation, and light emission. Trifluoromethanesulfonate lithiumexhibits strong ion pairing in non-aqueous electrolytes, but its electrochemical stability window is narrower than that of lithium bistrifluoromethylsulfonyl imidee .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-121564

Radermachol	Natural Products Radermachera xylocarpa (Roxb.) Roxb. ex K.Schum. Bignoniaceae Plants Source Classification	Fluorescent Dye
Radermachol is a red pigment that can be synthesized in four steps via a key ytterbium triflate-catalyzed furan cyclization and intramolecular nucleophilic acylation reaction .

Cat. No.	Product Name	Chemical Structure

HY-W767484

Nicotinamide riboside-d4 triflate
Nicotinamide riboside-d₄ (triflate) (Nicotinamide riboside-d₄ triflate (d3-major)a/b mixture) is deuterium labeled Nicotinamide riboside (triflate) .

HY-142448S

Nicotinic acid riboside methyl ester-d4 triflate
Nicotinic acid riboside methyl ester-d4 triflate is the deuterium labeled Nicotinic acid riboside methyl ester triflate .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Triflate

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Natural
Products