108530-10-5
108530-10-5
Chemical Structure
7-Coumaryl triflate
- CAS No.: 108530-10-5
- Formula:C10H5F3O5S
- Molecular Weight:294.20
IUPAC Name: 2-oxo-2H-chromen-7-yl trifluoromethanesulfonate
InChIKey: RHZZAJVDTLUWRD-UHFFFAOYSA-N
SMILES: O=C1OC=2C=C(OS(=O)(=O)C(F)(F)F)C=CC2C=C1
Biological Activity: 7-Coumaryl triflate is a type 17β-HSD1 inhibitor of 17β-hydroxysteroid dehydrogenase. Its IC50 is 360 nM and Ki is 173 nM. 7-Coumaryl triflate shows selectivity for 17β-HSD2 and has no detectable affinity for ERα or ERβ. 7-Coumaryl triflate can be used in related research on hormone-dependent breast cancer[1].
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7-Coumaryl triflate | 7-Coumaryl triflate is a type 17β-HSD1 inhibitor of 17β-hydroxysteroid dehydrogenase. Its IC50 is 360 nM and Ki is 173 nM. 7-Coumaryl triflate shows selectivity for 17β-HSD2 and has no detectable affinity for ERα or ERβ. 7-Coumaryl triflate can be used in related research on hormone-dependent breast cancer. | |||||||||||||||||||||
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