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Tyr-397

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Anaplastic lymphoma kinase (ALK) (1) Apoptosis (1) Caspase (1) FAK (4) MMP (1) Reference Standards (1) YTHDF (1)
By Research Areas:	Cancer (4) Inflammation/Immunology (1)

Inhibitors & Agonists

Antibodies

Targets Recommended: Tyrosine Hydroxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12289A

Defactinib hydrochloride 55+ Cited Publications VS-6063 hydrochloride; PF 04554878 hydrochloride	FAK	Cancer
Defactinib hydrochloride (VS-6063 hydrochloride; PF 04554878 hydrochloride) is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.

HY-15841

CEP-37440	Anaplastic lymphoma kinase (ALK) FAK	Cancer
CEP-37440 is a potent, orally active dual FAK/ALK inhibitor with IC₅₀ values of 2.3 nM and 3.5 nM for FAK and ALK, respectively. CEP-37440 decreases the cell proliferation by blocking the autophosphorylation kinase activity of FAK1 (Tyr 397) .

HY-176848

SKLB-Y13	YTHDF Apoptosis MMP Caspase	Cancer
SKLB-Y13 is a selective YTHDF1 inhibitor with an IC₅₀ of 0.76 μM and a K_D of 5.097 μM. SKLB-Y13 binds to the Tyr397 and Trp470 residues in the m ⁶A-binding pocket of YTHDF1, disrupting the interaction between YTHDF1 and m ⁶A-modified mRNA. SKLB-Y13 inhibits cancer cell proliferation and promotes apoptosis. SKLB-Y13 is applicable to breast cancer-related research .

HY-12289AR

Defactinib hydrochloride (Standard) VS-6063 hydrochloride (Standard); PF 04554878 hydrochloride (Standard)	FAK Reference Standards	Cancer
Defactinib (hydrochloride) (Standard) is the analytical standard of Defactinib (hydrochloride). This product is intended for research and analytical applications. Defactinib hydrochloride (VS-6063 hydrochloride; PF 04554878 hydrochloride) is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.

HY-181487

FAK activator-1	FAK	Inflammation/Immunology
FAK activator-1 is a FAK activator and mucosal healing inducer.FAK activator-1 increases FAK phosphorylation at Tyr-397, promoting FAK activation.FAK activator-1 promotes mucosal healing.FAK activator-1 can be used for the research of nsaid-associated gastrointestinal mucosal injury .

Host:	Rabbit (3)
Reactivity:	Human (3) Rat (2) Mouse (3)
Application:	ICC/IF (3) WB (3) ELISA (1)
Isotype:	IgG (2) IgG, Kappa (1)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Phosphorylated (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80460

	*Phospho-FAK (Tyr397) Antibody (YA198)*	WB, ICC/IF	Human, Mouse
	Phospho-FAK (Tyr397) Antibody (YA198) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-FAK (Tyr397).

HY-P87691

	*Phospho-FAK (Tyr397) Antibody (YA7376)*	WB, ICC/IF, ELISA	Human, Mouse, Rat
	Phospho-FAK (Tyr397) Antibody (YA7376) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Phospho-FAK (Tyr397).

HY-P810639

	*Phospho-LYN (Tyr397)/LCK (Tyr394)/HCK (Tyr411)/BLK (Tyr389) Antibody (YA9901)* LYN; JTK8; Tyrosine-protein kinase Lyn; Lck/Yes-related novel protein Tyrosine kinase; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn	WB, ICC/IF	Human, Mouse, Rat
	Phospho-LYN (Tyr397)/LCK (Tyr394)/HCK (Tyr411)/BLK (Tyr389) Antibody (YA9901) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-LYN (Tyr397)/LCK (Tyr394)/HCK (Tyr411)/BLK (Tyr389).

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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