2. Protein Tyrosine Kinase/RTK
  3. FAK
  4. FAK activator-1

FAK activator-1 is a FAK activator and mucosal healing inducer.FAK activator-1 increases FAK phosphorylation at Tyr-397, promoting FAK activation.FAK activator-1 promotes mucosal healing.FAK activator-1 can be used for the research of nsaid-associated gastrointestinal mucosal injury.

For research use only. We do not sell to patients.

FAK activator-1

FAK activator-1 Chemical Structure

CAS No. : 2769848-56-6

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

FAK activator-1 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

FAK activator-1 is a FAK activator and mucosal healing inducer.FAK activator-1 increases FAK phosphorylation at Tyr-397, promoting FAK activation.FAK activator-1 promotes mucosal healing.FAK activator-1 can be used for the research of nsaid-associated gastrointestinal mucosal injury[1].

In Vitro

FAK activator-1 (5aHCl) (10-100 nM; 1 h) activates FAK in suspended Caco-2 cells[1].
FAK activator-1 (5aHCl) (100 nM; 24 h) promotes wound healing of Caco-2 intestinal epithelial monolayers by enhancing cell migration rather than proliferation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FAK activator-1 Related Antibodies

Western Blot Analysis[1]

Cell Line: human Caco-2 intestinal epithelial cells
Concentration: 10 nM, 100 nM
Incubation Time: 1 h
Result: Increased the ratio of FAK-Tyr-397 phosphorylation to total FAK protein by 1.25 ± 0.08-fold at 10 nM compared to vehicle control.
Increased the ratio of FAK-Tyr-397 phosphorylation to total FAK protein by 1.25 ± 0.08-fold at 100 nM compared to vehicle control.

Cell Migration Assay[1]

Cell Line: human Caco-2 intestinal epithelial cells
Concentration: 100 nM
Incubation Time: 24 h
Result: Promoted Caco-2 monolayer wound closure with an EC50 of 3.01 ± 0.52 nM.
Significantly accelerated wound closure at 100 nM compared to vehicle control.
Retained stimulatory effect on wound closure at 100 nM when co-treated with 4 mM hydroxyurea to inhibit cell proliferation.
Parmacokinetics
Species Dose Route Cmax Tmax AUC T1/2
Rat[1] 10 mg/kg p.o. 967 ng/mL 1 h 3149 mg·h/L 3 h
Molecular Weight

473.92

Formula

C21H27ClF3N5O2
CAS No.
SMILES

CN(C(C1=CC=NC=C1)CNC(NC2=CC(C(F)(F)F)=CC=C2N3CCOCC3)=O)C.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

FAK activator-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FAK activator-12769848-56-6FAK activator1FAK activator 1FAKPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinasemucosal healingintestinal epithelial monolayerTyr-397nsaid-associated gastrointestinal mucosal injuryCaco-2 cellsFocal Adhesion KinaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
FAK activator-1
Cat. No.:
HY-181487
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.