FAK activator-1
FAK activator-1 is a FAK activator and mucosal healing inducer.FAK activator-1 increases FAK phosphorylation at Tyr-397, promoting FAK activation.FAK activator-1 promotes mucosal healing.FAK activator-1 can be used for the research of nsaid-associated gastrointestinal mucosal injury.
For research use only. We do not sell to patients.
- CAS No.: 2769848-56-6
- Formula: C21H27ClF3N5O2
- Molecular Weight:473.92
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
FAK activator-1 (5aHCl) (10-100 nM; 1 h) activates FAK in suspended Caco-2 cells[1].
FAK activator-1 (5aHCl) (100 nM; 24 h) promotes wound healing of Caco-2 intestinal epithelial monolayers by enhancing cell migration rather than proliferation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human Caco-2 intestinal epithelial cells
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Concentration:10 nM, 100 nM
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Incubation Time:1 h
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Result:Increased the ratio of FAK-Tyr-397 phosphorylation to total FAK protein by 1.25 ± 0.08-fold at 10 nM compared to vehicle control.
Increased the ratio of FAK-Tyr-397 phosphorylation to total FAK protein by 1.25 ± 0.08-fold at 100 nM compared to vehicle control.
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Cell Line:human Caco-2 intestinal epithelial cells
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Concentration:100 nM
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Incubation Time:24 h
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Result:Promoted Caco-2 monolayer wound closure with an EC50 of 3.01 ± 0.52 nM.
Significantly accelerated wound closure at 100 nM compared to vehicle control.
Retained stimulatory effect on wound closure at 100 nM when co-treated with 4 mM hydroxyurea to inhibit cell proliferation.
| Species | Dose | Route | Cmax | Tmax | AUC | T1/2 |
|---|---|---|---|---|---|---|
| Rat[1] | 10 mg/kg | p.o. | 967 ng/mL | 1 h | 3149 mg·h/L | 3 h |
Chemical Information
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CAS No. 2769848-56-6
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Molecular Weight 473.92
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Formula C21H27ClF3N5O2
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SMILES
CN(C(C1=CC=NC=C1)CNC(NC2=CC(C(F)(F)F)=CC=C2N3CCOCC3)=O)C.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FAK activator-1 Related Classifications
HY-181487 Related Classifications
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