Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
UK33274
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "UK33274" in MCE Product Catalog:
3
Category:
Target:
3
Target:
Research Areas:
Doxazosin mesylate (UK 33274 mesylate) is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors.
Cat. No.: HY-B0098AR
CAS No.: 77883-43-3
Synonyms: UK 33274 mesylate (Standard)
Research Areas:
Doxazosin (mesylate) (Standard) is the analytical standard of Doxazosin (mesylate). This product is intended for research and analytical applications. Doxazosin mesylate (UK 33274) is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors.
Cat. No.: HY-W753806
CAS No.: 70918-01-3
Synonyms: UK 33274 hydrochloride
Target:
Research Areas:
Doxazosin hydrochloride (UK 33274 hydrochloride) is a compound used to inhibit hypertension and prostate hyperplasia, with activity that inhibits postsynaptic α1-adrenoceptors on vascular smooth muscle. Doxazosin hydrochloride can cause vasodilation, thereby reducing peripheral vascular resistance. Doxazosin hydrochloride was found to inhibit the proliferation and migration of hepatic stellate cells in a mouse liver fibrosis model. Doxazosin hydrochloride regulates fibrosis, autophagy, and apoptosis of hepatic stellate cells by activating the PI3K/Akt/mTOR signaling pathway. Doxazosin hydrochloride also blocks autophagic flux and induces apoptosis of hepatic stellate cells .
Cat. No.: HY-B0098BS
CAS No.: 1219803-95-8
Synonyms: UK 33274-d8 hydrochloride
Cat. No.: HY-B0098B
CAS No.: 70918-17-1
Synonyms: (R)-UK 33274
Target:
Research Areas:
(R)-Doxazosin ((R)-UK 33274) is an isomer of Doxazosin, a selective and orally active a1-adrenoceptor agonist. Doxazosin can be used for systemic antihypertensive and ocular hypotensive. Doxazosin exerts its antihypertensive effect by reducing total peripheral resistance by selective postsynaptic a1-blockade, without reducing cardiac output. Doxazosin can significantly lower both standing and supine blood pressure .
Cat. No.: HY-B0098S
CAS No.: 1126848-44-9
Synonyms: UK 33274-d8
Cat. No.: HY-B0098C
CAS No.: 104874-86-4
Synonyms: (S)-UK 33274
Target:
Research Areas:
(S)-Doxazosin is a long-acting selective α1-adrenoceptor antagonist. (S)-Doxazosin exhibits antihypertensive activity through lowering total perioheral resistance by selective postsynaptic α1-blockade. (S)-Doxazosin reduces blood pressure in dog model with experimentally induced renal hypertension. (S)-Doxazosin can alleviate bladder outflow obstruction. (S)-Doxazosin can also be studied in mental health disorder-related research .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
